Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease

Ittner, Lars M. and Gotz, Jürgen (2011) Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease. Nature Reviews Neuroscience, 12 2: 67-72. doi:10.1038/nrn2967

Author Ittner, Lars M.
Gotz, Jürgen
Title Amyloid-β and tau - A toxic pas de deux in Alzheimer's disease
Journal name Nature Reviews Neuroscience   Check publisher's open access policy
ISSN 1471-003X
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/nrn2967
Open Access Status Not yet assessed
Volume 12
Issue 2
Start page 67
End page 72
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 2700 Medicine
2800 Neuroscience
Abstract Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both amyloid-β and tau have been extensively studied individually with regard to their separate modes of toxicity, more recently new light has been shed on their possible interactions and synergistic effects in Alzheimer's disease. Here, we review novel findings that have shifted our understanding of the role of tau in the pathogenesis of Alzheimer's disease towards being a crucial partner of amyloid-β. As we gain a deeper understanding of the different cellular functions of tau, the focus shifts from the axon, where tau has a principal role as a microtubule-associated protein, to the dendrite, where it mediates amyloid-β toxicity.
Keyword Neurosciences
Neurosciences & Neurology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 508 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 524 times in Scopus Article | Citations
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