Modes of Aβ toxicity in Alzheimer's disease

Gotz, Jurgen, Eckert, Anne, Matamales, Miriam, Ittner, Lars M. and Liu, Xin (2011) Modes of Aβ toxicity in Alzheimer's disease. Cellular and Molecular Life Sciences, 68 20: 3359-3375. doi:10.1007/s00018-011-0750-2


Author Gotz, Jurgen
Eckert, Anne
Matamales, Miriam
Ittner, Lars M.
Liu, Xin
Title Modes of Aβ toxicity in Alzheimer's disease
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
1420-9071
Publication date 2011-01-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00018-011-0750-2
Open Access Status Not Open Access
Volume 68
Issue 20
Start page 3359
End page 3375
Total pages 17
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Language eng
Abstract Alzheimer's disease (AD) is reaching epidemic proportions, yet a cure is not yet available. While the genetic causes of the rare familial inherited forms of AD are understood, the causes of the sporadic forms of the disease are not. Histopathologically, these two forms of AD are indistinguishable: they are characterized by amyloid-β (Aβ) peptide-containing amyloid plaques and tau-containing neurofibrillary tangles. In this review we compare AD to frontotemporal dementia (FTD), a subset of which is characterized by tau deposition in the absence of overt plaques. A host of transgenic animal AD models have been established through the expression of human proteins with pathogenic mutations previously identified in familial AD and FTD. Determining how these mutant proteins cause disease in vivo should contribute to an understanding of the causes of the more frequent sporadic forms. We discuss the insight transgenic animal models have provided into Aβ and tau toxicity, also with regards to mitochondrial function and the crucial role tau plays in mediating Aβ toxicity. We also discuss the role of miRNAs in mediating the toxic effects of the Aβ peptide.
Keyword Alzheimer
Amyloid
Frontotemporal dementia
Fyn
miRNA
Mitochondria
Oligomer
Proteomic
Tau
Transgenic
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ALTF 1228-2010
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
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