Animal models reveal role for tau phosphorylation in human disease

Gotz, Jurgen, Gladbach, Amadeus, Pennanen, Luis, van Eersel, Janet, Schild, Andreas, David, Della and Ittner, Lars M. (2010) Animal models reveal role for tau phosphorylation in human disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1802 10: 860-871. doi:10.1016/j.bbadis.2009.09.008


Author Gotz, Jurgen
Gladbach, Amadeus
Pennanen, Luis
van Eersel, Janet
Schild, Andreas
David, Della
Ittner, Lars M.
Title Animal models reveal role for tau phosphorylation in human disease
Journal name Biochimica et Biophysica Acta - Molecular Basis of Disease   Check publisher's open access policy
ISSN 0925-4439
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.bbadis.2009.09.008
Open Access Status Not Open Access
Volume 1802
Issue 10
Start page 860
End page 871
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.
Keyword Alzheimer's disease
Amyloid
Drosophila
Frontotemporal dementia
Kinase
Mice
Nematode
Phosphatase
Phosphorylation
Tau
Transgenic
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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