Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology

David, Della C., Hoerndli, Frederic and Gotz, Juergen (2005) Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology. Progress in Neurobiology, 76 3: 153-168. doi:10.1016/j.pneurobio.2005.07.001


Author David, Della C.
Hoerndli, Frederic
Gotz, Juergen
Title Functional genomics meets neurodegenerative disorders: part I: transcriptomic and proteomic technology
Journal name Progress in Neurobiology   Check publisher's open access policy
ISSN 0301-0082
1873-5118
Publication date 2005-06-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.pneurobio.2005.07.001
Open Access Status Not yet assessed
Volume 76
Issue 3
Start page 153
End page 168
Total pages 16
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
Transcriptomics and proteomics are increasingly applied to gain a mechanistic insight into neurodegenerative disorders. These techniques not only identify distinct, differentially expressed mRNAs and proteins but are also employed to dissect signaling pathways and reveal networks by using an integrated approach. In part I of this back-to-back review, technical aspects are discussed: in the transcriptomics section, which includes enrichment by laser microcapture dissection, we comment on qRT-PCR, SAGE, subtractive hybridization, differential display and microarrays, including software packages. In the proteomics section we discuss two-dimensional (2D) gel electrophoresis, liquid chromatography, methods to label and enrich specific proteins or peptides, and different types of mass spectrometers. These tools have been applied to a range of neurodegenerative disorders and are discussed and integrated in part II (Functional Genomics meets neurodegenerative disorders. Part II: Application and data integration).
Keyword Alzheimer's disease
Amyotrophic Lateral Sclerosis
Animal models
Functional Genomics
Neurodegenerative disorders
Parkinson's disease
Proteomics
Transcriptomics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Centre for Ageing Dementia Research Publications
 
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