Endocellular regulation by free radicals and hydrogen peroxide: key determinants of the inflammatory response

Vitetta, Luis and Linnane, Anthony W. (2014) Endocellular regulation by free radicals and hydrogen peroxide: key determinants of the inflammatory response. Inflammopharmacology, Online First 1-4. doi:10.1007/s10787-014-0199-7

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Author Vitetta, Luis
Linnane, Anthony W.
Title Endocellular regulation by free radicals and hydrogen peroxide: key determinants of the inflammatory response
Journal name Inflammopharmacology   Check publisher's open access policy
ISSN 0925-4692
Publication date 2014-02-22
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s10787-014-0199-7
Open Access Status Not Open Access
Volume Online First
Start page 1
End page 4
Total pages 4
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Language eng
Formatted abstract
The formations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been considered as major contributors to the dysregulation of the inflammatory response. Reactive oxygen species and RNS productions often are reported to be associated with the development of chronic diseases and acceleration of the aging process. Mechanistically, this association has linked the phenomena of oxidative stress with the occurrence of random deleterious modifications of macromolecules with progressive development of pro-inflammatory conditions promoting age-associated systemic diseases. On the contrary the so-called random modification of macromolecules is incorrect rather ROS and RNS are molecular regulators (second messengers) and not universal toxins whose overproduction should be annulled by antioxidants. We have previously reviewed the physiological role of superoxide anion (and hydrogen peroxide) and nitric oxide (and peroxynitrite) and concluded that these reactive molecular species behave as pro-oxidant second messengers. Reactive oxygen species and RNS are produced at specific cellular locations and are essential for both the normal physiological function of the metabolome and the regulated inflammatory response. This brings into question the whole concept of the orally administering of antioxidant molecular species to down-regulate or abrogate an overproduction of free radical activity. There are no human clinical trials that demonstrate that small molecules, the so-called antioxidants (e.g., vitamins C, vitamin E and beta-carotene), confer a favorable clinical outcome of long-lasting control of inflammation.
Keyword Inflammation
Reactive oxygen species
Reactive nitrogen species
Free radicals
Protein oxidations
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 22 February 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Wed, 26 Feb 2014, 15:53:41 EST by Dr Luis Vitetta on behalf of Medicine - Princess Alexandra Hospital