Associations between lifestyle and cognitive function over time in women aged 40-79 years

Lo, Ada H. Y., Woodman, Richard J., Pachana, Nancy A., Byrne, Gerard J. and Sachdev, Perminder S. (2014) Associations between lifestyle and cognitive function over time in women aged 40-79 years. Journal of Alzheimer's Disease, 39 2: 371-383. doi:10.3233/JAD-130971


Author Lo, Ada H. Y.
Woodman, Richard J.
Pachana, Nancy A.
Byrne, Gerard J.
Sachdev, Perminder S.
Title Associations between lifestyle and cognitive function over time in women aged 40-79 years
Journal name Journal of Alzheimer's Disease   Check publisher's open access policy
ISSN 1387-2877
1875-8908
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.3233/JAD-130971
Open Access Status DOI
Volume 39
Issue 2
Start page 371
End page 383
Total pages 13
Editor Maheen Adamson
Place of publication Amsterdam, Netherlands
Publisher I O S Press
Language eng
Abstract Background: Smoking, excessive drinking, and physical inactivity are associated with reduced cognitive function but the independence, domain specific cognitive effects, and trajectories of these associations are not firmly established.
Formatted abstract
Background: Smoking, excessive drinking, and physical inactivity are associated with reduced cognitive function but the independence, domain specific cognitive effects, and trajectories of these associations are not firmly established.

Objective: Our aim was to examine these lifestyle-cognitive function associations in middle-to-older aged women across time.

Methods: Cohort study design with repeat surveys (2001, 2005, and 2008). Participants were volunteers from a random sample of Australian women on the Brisbane electoral roll; mean (±SD) age 60 ± 11 years in 2001. Outcome measures were the Mini-Mental State Examination (MMSE), Auditory Delayed Index (ADI), Visual Delayed Index (VDI), Working Memory Index (WMI), and Processing Speed Index (PSI).

Results: 489 women completed cognitive testing in 2001, 451 in 2005, and 376 in 2008. Mean (±SD) cognitive scores in 2001 were MMSE: 29.1 ± 1.2, ADI: 104.6 ± 13.4, VDI: 107.2 ± 14.0, WMI: 104.1 ± 12.3, and PSI: 102.7 ± 11.8. Multivariate adjusted mean scores (95% CI) over the 7-year study period were higher for moderate drinkers than non-drinkers for the MMSE (β = 0.32; 0.04, 0.61), the VDI (β = 4.33; 0.96, 7.70), and the WMI (β = 3.21; 0.34, 6.07). Current smokers performed worse than never-smokers for the MMSE (β = −0.35; 0.64, −0.06), the VDI (β = −3.91; −7.57, −0.26), the WMI (β = −3.42; −6.67, −0.18), and the PSI (β = −5.89; −8.91, −2.87). PSI was higher in women performing strenuous physical activity compared to inactive women (β = 2.14; 0.37, 3.90). None of the three lifestyle parameters influenced the changes in cognition across time.

Conclusions: Alcohol and exercise were associated with selective protective effects and tobacco with selective harmful effects on cognitive function in middle-to-older aged women. Associations remained consistent across time.
Keyword Cognitive function
Drinking
Physical activity
Smoking
Women
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 456182
Institutional Status UQ
Additional Notes Online Date Friday, November 08, 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 26 Feb 2014, 00:37:22 EST by Sheila Cleary on behalf of School of Psychology