Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

Permuth-Wey, J., Lawrenson, K., Shen, H. C., Velkova, A., Tyrer, J. P., Chen, Z., Lin, H. -Y., Ann Chen, Y., Tsai, Y. -Y., Qu, X., Ramus, S. J., Karevan, R., Lee, J., Lee, N., Larson, M. C., Aben, K. K., Anton-Culver, H., Antonenkova, N., Antoniou, A. C., Armasu, S. M., Bacot, F., Baglietto L., Bandera, E. V., Barnholtz-Sloan, J., Beckmann, M. W., Birrer, M. J., Bloom, G., Bogdanova, N., Brinton, L. A., Brooks-Wilson, A., Brown, R., Butzow, R., Cai, Q., Campbell, I., Chang-Claude, J., Chanock, S., Chenevix-Trench, G., Cheng, J. Q., Cicek, M. S., Coetzee, G. A., Cook, L. S., Couch, F. J., Cramer, D. W., Cunningham, J. M., Dansonka-Mieszkowska, A., Despierre, E., Doherty, J. A., Dork, T., Du Bois, A., Durst, M., Easton, D. F., Eccles, D., Edwards, R., Ekici, A. B., Fasching, P. A., Fenstermacher, D. A., Flanagan, J. M., Garcia-Closas, M., Gentry-Maharaj, A., Giles, G. G., Glasspool, R. M., Gonzalez-Bosquet, J., Goodman, M. T., Gore, M., Gorski, B., Gronwald, J., Hall, P., Halle, M. K., Harter, P., Heitz, F., Hillemanns, P., Hoatlin, M., Hogdall, C. K., Hogdall, E., Hosono, S., Jakubowska, A., Jensen, A., Jim, H., Kalli, K. R., Karlan, B. Y., Kaye, S. B., Kelemen, L. E., Kiemeney, L. A., Kikkawa, F., Konecny, G. E., Krakstad, C., Kruger Kjaer, S., Kupryjanczyk, J., Lambrechts, D., Lambrechts, S., Lancaster, J. M., Le, N. D., Leminen, A., Levine, D. A., Liang, D., Kiong Lim, B., Lin, J., Lissowska, J., Lu, K. H., Lubinski, J., Lurie, G., Massuger, L. F. A. G., Matsuo, K., McGuire, V., McLaughlin, J. R., Menon, U., Modugno, F., Moysich, K. B., Nakanishi, T., Narod, S. A., Nedergaard, L., Ness, R. B., Nevanlinna, H., Nickels, S., Noushmehr, H., Odunsi, K., Olson, S. H., Orlow, I., Paul, J., Pearce, C. L., Pejovic, T., Pelttari, L. M., Pike, M. C., Poole, E. M., Raska, P., Renner, S. P., Risch, H. A., Rodriguez-Rodriguez, L., Anne Rossing, M., Rudolph, A., Runnebaum, I. B., Rzepecka, I. K., Salvesen, H. B., Schwaab, I., Severi, G., Shridhar, V., Shu, X. -O., Shvetsov, Y. B., Sieh, W., Song, H., Southey, M. C., Spiewankiewicz, B., Stram, D., Sutphen, R., Teo, S. -H., Terry, K. L., Tessier, D. C., Thompson, P. J., Tworoger, S. S., Van Altena, A. M., Vergote, I., Vierkant, R. A., Vincent, D., Vitonis, A. F., Wang-Gohrke, S., Palmieri Weber, R., Wentzensen, N., Whittemore, A. S., Wik, E., Wilkens, L. R., Winterhoff, B., Ling Woo, Y., Wu, A. H., Xiang, Y. -B., Yang, H. P., Zheng, W., Ziogas, A., Zulkifli, F., Phelan, C. M., Iversen, E., Schildkraut, J. M., Berchuck, A., Fridley, B. L., Goode, E. L., Pharoah, P. D. P., Monteiro, A. N. A., Sellers, T. A. and Gayther, S. A. (2013) Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nature Communications, 4 Article number 1627: 1-12. doi:10.1038/ncomms2613

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Author Permuth-Wey, J.
Lawrenson, K.
Shen, H. C.
Velkova, A.
Tyrer, J. P.
Chen, Z.
Lin, H. -Y.
Ann Chen, Y.
Tsai, Y. -Y.
Qu, X.
Ramus, S. J.
Karevan, R.
Lee, J.
Lee, N.
Larson, M. C.
Aben, K. K.
Anton-Culver, H.
Antonenkova, N.
Antoniou, A. C.
Armasu, S. M.
Bacot, F.
Baglietto L.
Bandera, E. V.
Barnholtz-Sloan, J.
Beckmann, M. W.
Birrer, M. J.
Bloom, G.
Bogdanova, N.
Brinton, L. A.
Brooks-Wilson, A.
Brown, R.
Butzow, R.
Cai, Q.
Campbell, I.
Chang-Claude, J.
Chanock, S.
Chenevix-Trench, G.
Cheng, J. Q.
Cicek, M. S.
Coetzee, G. A.
Cook, L. S.
Couch, F. J.
Cramer, D. W.
Cunningham, J. M.
Dansonka-Mieszkowska, A.
Despierre, E.
Doherty, J. A.
Dork, T.
Du Bois, A.
Durst, M.
Easton, D. F.
Eccles, D.
Edwards, R.
Ekici, A. B.
Fasching, P. A.
Fenstermacher, D. A.
Flanagan, J. M.
Garcia-Closas, M.
Gentry-Maharaj, A.
Giles, G. G.
Glasspool, R. M.
Gonzalez-Bosquet, J.
Goodman, M. T.
Gore, M.
Gorski, B.
Gronwald, J.
Hall, P.
Halle, M. K.
Harter, P.
Heitz, F.
Hillemanns, P.
Hoatlin, M.
Hogdall, C. K.
Hogdall, E.
Hosono, S.
Jakubowska, A.
Jensen, A.
Jim, H.
Kalli, K. R.
Karlan, B. Y.
Kaye, S. B.
Kelemen, L. E.
Kiemeney, L. A.
Kikkawa, F.
Konecny, G. E.
Krakstad, C.
Kruger Kjaer, S.
Kupryjanczyk, J.
Lambrechts, D.
Lambrechts, S.
Lancaster, J. M.
Le, N. D.
Leminen, A.
Levine, D. A.
Liang, D.
Kiong Lim, B.
Lin, J.
Lissowska, J.
Lu, K. H.
Lubinski, J.
Lurie, G.
Massuger, L. F. A. G.
Matsuo, K.
McGuire, V.
McLaughlin, J. R.
Menon, U.
Modugno, F.
Moysich, K. B.
Nakanishi, T.
Narod, S. A.
Nedergaard, L.
Ness, R. B.
Nevanlinna, H.
Nickels, S.
Noushmehr, H.
Odunsi, K.
Olson, S. H.
Orlow, I.
Paul, J.
Pearce, C. L.
Pejovic, T.
Pelttari, L. M.
Pike, M. C.
Poole, E. M.
Raska, P.
Renner, S. P.
Risch, H. A.
Rodriguez-Rodriguez, L.
Anne Rossing, M.
Rudolph, A.
Runnebaum, I. B.
Rzepecka, I. K.
Salvesen, H. B.
Schwaab, I.
Severi, G.
Shridhar, V.
Shu, X. -O.
Shvetsov, Y. B.
Sieh, W.
Song, H.
Southey, M. C.
Spiewankiewicz, B.
Stram, D.
Sutphen, R.
Teo, S. -H.
Terry, K. L.
Tessier, D. C.
Thompson, P. J.
Tworoger, S. S.
Van Altena, A. M.
Vergote, I.
Vierkant, R. A.
Vincent, D.
Vitonis, A. F.
Wang-Gohrke, S.
Palmieri Weber, R.
Wentzensen, N.
Whittemore, A. S.
Wik, E.
Wilkens, L. R.
Winterhoff, B.
Ling Woo, Y.
Wu, A. H.
Xiang, Y. -B.
Yang, H. P.
Zheng, W.
Ziogas, A.
Zulkifli, F.
Phelan, C. M.
Iversen, E.
Schildkraut, J. M.
Berchuck, A.
Fridley, B. L.
Goode, E. L.
Pharoah, P. D. P.
Monteiro, A. N. A.
Sellers, T. A.
Gayther, S. A.
Title Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ncomms2613
Open Access Status DOI
Volume 4
Issue Article number 1627
Start page 1
End page 12
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134 controls from 43 studies genotyped through the Collaborative Oncological Gene-environment Study. We identify several miRSNPs associated with invasive serous EOC risk (odds ratio=1.12, P=10-8) mapping to an inversion polymorphism at 17q21.31. Additional genotyping of non-miRSNPs at 17q21.31 reveals stronger signals outside the inversion (P=10-10). Variation at 17q21.31 is associated with neurological diseases, and our collaboration is the first to report an association with EOC susceptibility. An integrated molecular analysis in this region provides evidence for ARHGAP27 and PLEKHM1 as candidate EOC susceptibility genes.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 223175-HEALTH-F2-2009-223175
4 PO5C 028 14
01 GB 9401
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 57 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 55 times in Scopus Article | Citations
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Created: Sun, 23 Feb 2014, 19:48:20 EST by Matthew Lamb on behalf of School of Medicine