A variant in FTO shows association with melanoma risk not due to BMI

Iles M.M., Law M.H., Stacey S.N., Han J., Fang S., Pfeiffer R., Harland M., MacGregor S., Taylor J.C., Aben K.K., Akslen L.A., Avril M.-F., Azizi E., Bakker B., Benediktsdottir K.R., Bergman W., Scarra G.B., Brown K.M., Calista D., Chaudru V., Fargnoli M.C., Cust A.E., Demenais F., De Waal A.C., Debniak T., Elder D.E., Friedman E., Galan P., Ghiorzo P., Gillanders E.M., Goldstein A.M., Gruis N.A., Hansson J., Helsing P., Hocevar M., Hoiom V., Hopper J.L., Ingvar C., Janssen M., Jenkins M.A., Kanetsky P.A., Kiemeney L.A., Lang J., Lathrop G.M., Leachman S., Lee J.E., Lubinski J., MacKie R.M., Mann G.J., Martin N.G., Mayordomo J.I., Molven A., Mulder S., Nagore E., Novakovic S., Okamoto I., Olafsson J.H., Olsson H., Pehamberger H., Peris K., Grasa M.P., Planelles D., Puig S., Puig-Butille J.A., Randerson-Moor J., Requena C., Rivoltini L., Rodolfo M., Santinami M., Sigurgeirsson B., Snowden H., Song F., Sulem P., Thorisdottir K., Tuominen R., Van Belle P., Van Der Stoep N., Van Rossum M.M., Wei Q., Wendt J., Zelenika D., Zhang M., Landi M.T., Thorleifsson G., Bishop D.T., Amos C.I., Hayward N.K., Stefansson K., Bishop J.A.N. and Barrett J.H. (2013) A variant in FTO shows association with melanoma risk not due to BMI. Nature Genetics, 45 4: 428-432. doi:10.1038/ng.2571

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Author Iles M.M.
Law M.H.
Stacey S.N.
Han J.
Fang S.
Pfeiffer R.
Harland M.
MacGregor S.
Taylor J.C.
Aben K.K.
Akslen L.A.
Avril M.-F.
Azizi E.
Bakker B.
Benediktsdottir K.R.
Bergman W.
Scarra G.B.
Brown K.M.
Calista D.
Chaudru V.
Fargnoli M.C.
Cust A.E.
Demenais F.
De Waal A.C.
Debniak T.
Elder D.E.
Friedman E.
Galan P.
Ghiorzo P.
Gillanders E.M.
Goldstein A.M.
Gruis N.A.
Hansson J.
Helsing P.
Hocevar M.
Hoiom V.
Hopper J.L.
Ingvar C.
Janssen M.
Jenkins M.A.
Kanetsky P.A.
Kiemeney L.A.
Lang J.
Lathrop G.M.
Leachman S.
Lee J.E.
Lubinski J.
MacKie R.M.
Mann G.J.
Martin N.G.
Mayordomo J.I.
Molven A.
Mulder S.
Nagore E.
Novakovic S.
Okamoto I.
Olafsson J.H.
Olsson H.
Pehamberger H.
Peris K.
Grasa M.P.
Planelles D.
Puig S.
Puig-Butille J.A.
Randerson-Moor J.
Requena C.
Rivoltini L.
Rodolfo M.
Santinami M.
Sigurgeirsson B.
Snowden H.
Song F.
Sulem P.
Thorisdottir K.
Tuominen R.
Van Belle P.
Van Der Stoep N.
Van Rossum M.M.
Wei Q.
Wendt J.
Zelenika D.
Zhang M.
Landi M.T.
Thorleifsson G.
Bishop D.T.
Amos C.I.
Hayward N.K.
Stefansson K.
Bishop J.A.N.
Barrett J.H.
Title A variant in FTO shows association with melanoma risk not due to BMI
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2571
Open Access Status Not yet assessed
Volume 45
Issue 4
Start page 428
End page 432
Total pages 5
Place of publication New York, NY, U.S.A.
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID LSHC-CT-2006-018702
C588/A4994 and C588/A10589
C8216/A6129
C37059/A11941
CA83115
076113
ERC-2011-AdG 294576
2008W8JTPA_002
INCa-PL016
PRE05/ FD
AOM-07-195
C018
P.I. 09/01393
SE0728
71512-PR-2006-0356
12161
CA65558-02
CA83115
200071
WT084766/Z/08/Z
496674
1011143
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Sun, 23 Feb 2014, 19:13:01 EST by Matthew Lamb on behalf of School of Medicine