Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials

Abraham, Sam, Groves, Mitchell D, Trott, Darren J., Chapman, Toni A., Turner, Bernadette, Hornitzky, Michael and Jordan, David (2014) Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials. International Journal of Antimicrobial Agents, 43 2: 126-130. doi:10.1016/j.ijantimicag.2013.10.014


Author Abraham, Sam
Groves, Mitchell D
Trott, Darren J.
Chapman, Toni A.
Turner, Bernadette
Hornitzky, Michael
Jordan, David
Title Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials
Formatted title
Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials
Journal name International Journal of Antimicrobial Agents   Check publisher's open access policy
ISSN 0924-8579
1872-7913
Publication date 2014-02-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ijantimicag.2013.10.014
Volume 43
Issue 2
Start page 126
End page 130
Total pages 5
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2014
Language eng
Formatted abstract
Salmonella enterica is a zoonotic pathogen causing a variety of diseases in humans and animals. Many countries are reporting an increase in the prevalence of multidrug-resistant (MDR) S. enterica in food animals. The aim of this study was to determine whether S. enterica isolated from livestock in New South Wales, Australia, have similar resistance traits to those reported internationally. Salmonella enterica (n = 165) from clinical infections in food animals between 2007 and 2011 were serotyped and tested for susceptibility to 18 antimicrobials. Also, 22 antimicrobial resistance genes (ARGs), 3 integrons and 18 plasmid replicon types were screened for using PCR. Most isolates (66.1%) remained susceptible to all antimicrobials; 8.5% of the isolates were resistant to four or more antimicrobials. Antimicrobials with the highest prevalence of resistance were sulfafurazole (28.5%), ampicillin (17.0%), tetracycline (15.8%) and trimethoprim (8.5%). There was no resistance to fluoroquinolones or third-generation cephalosporins. The most common ARGs were blaTEM (15.2%), sul2 (10.3%), tetB (9.1%), tetA (5.5%), aphA1 (4.8%) and dhfrV (4.8%). Class 1 integrons (7.9%) and IncFIIA (69.7%) were the most commonly detected integron and plasmid replicon types, respectively. Class 1 integrons were positively associated with MDR phenotypes and ARG carriage (P ≤ 0.001). Internationally prominent MDR serovars associated with severe disease in humans (e.g. AmpC-positive Salmonella Newport) were not detected. Overall, the comparatively favourable resistance status of S. enterica in Australian livestock represents minimal public health risk associated with MDR strains and supports a conservative approach to the registration of antimicrobial drug classes in food-producing animals.
Keyword Animals
Antimicrobial resistance
Australia
Plasmid replicon
Salmonella
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Agriculture and Food Sciences
Official 2014 Collection
 
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