Loss of MEC-17 leads to microtubule instability and axonal degeneration

Neumann, Brent and Hilliard, Massimo A. (2014) Loss of MEC-17 leads to microtubule instability and axonal degeneration. Cell Reports, 6 1: 93-103. doi:10.1016/j.celrep.2013.12.004

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Author Neumann, Brent
Hilliard, Massimo A.
Title Loss of MEC-17 leads to microtubule instability and axonal degeneration
Journal name Cell Reports   Check publisher's open access policy
ISSN 2211-1247
Publication date 2014-01-16
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.celrep.2013.12.004
Open Access Status DOI
Volume 6
Issue 1
Start page 93
End page 103
Total pages 11
Place of publication New York, United States
Publisher Elsevier
Language eng
Formatted abstract
Axonal degeneration arises as a consequence of neuronal injury and is a common hallmark of a number of neurodegenerative diseases. However, the genetic causes and the cellular mechanisms that trigger this process are still largely unknown. Based on forward genetic screening in C.elegans, we have identified the α-tubulin acetyltransferase gene mec-17 as causing spontaneous, adult-onset, and progressive axonal degeneration. Loss of MEC-17 leads to microtubule instability, a reduction in mitochondrial number, and disrupted axonal transport, with altered distribution of both mitochondria and synaptic components. Furthermore, mec-17-mediated axonal degeneration occurs independently from its acetyltransferase domain; is enhanced by mutation of coel-1, a tubulin-associated molecule; and correlates with the animal's body length. This study therefore identifies a critical role for the conserved microtubule-associated protein MEC-17 in preserving axon integrity and preventing axonal degeneration.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 26 December 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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