The spread and acquisition of NDM-1: a multifactorial problem

Wailan, Alexander M. and Paterson, David L. (2014) The spread and acquisition of NDM-1: a multifactorial problem. Expert Review of Anti-Infective Therapy, 12 1: 91-115. doi:10.1586/14787210.2014.856756


Author Wailan, Alexander M.
Paterson, David L.
Title The spread and acquisition of NDM-1: a multifactorial problem
Journal name Expert Review of Anti-Infective Therapy   Check publisher's open access policy
ISSN 1478-7210
1744-8336
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/14787210.2014.856756
Volume 12
Issue 1
Start page 91
End page 115
Total pages 25
Place of publication London, United Kingdom
Publisher Expert Reviews
Language eng
Abstract Bla NDM is a major mechanism of resistance of Gram-negative bacteria to β-lactam antibiotics including the carbapenems. bla NDM has been acquired by a large range of Gram-negative bacilli, especially by the Enterobacteriaceae and Acinetobacter spp. The combination of human factors (suboptimal antibiotic stewardship and infection control, movement of people between countries) plus bacterial factors (hospital adapted clones, environmental persistence and prolific horizontal gene transfer) have led to global spread of bla NDM at a rapid pace. Treatment options for New Delhi metallo-β-lactamase (NDM) producers are very limited. For serious infections, combination therapy including a polymyxin is preferred. However, resistance to polymyxins is emerging. Clearly, substantial international efforts must be made to control the spread of NDM producers or else many of the advances of modern medicine may be undermined by untreatable infections.
Keyword Community
Genetic mobilization
Medical tourism
NDM-1
Nosocomial
Plasmid
Polymyxins
Tn125
Transmission routes
Transposition
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 18 Feb 2014, 10:51:42 EST by System User on behalf of UQ Centre for Clinical Research