Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor

Mohammad, Shekeeb S., Sinclair, Kate, Pillai, Sekhar, Merheb, Vera, Aumann, Tim D., Gill, Deepak, Dale, Russell C. and Brilot, Fabienne (2014) Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor. Movement Disorders, 29 1: 117-122. doi:10.1002/mds.25623


Author Mohammad, Shekeeb S.
Sinclair, Kate
Pillai, Sekhar
Merheb, Vera
Aumann, Tim D.
Gill, Deepak
Dale, Russell C.
Brilot, Fabienne
Title Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor
Formatted title
Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor
Journal name Movement Disorders   Check publisher's open access policy
ISSN 0885-3185
1531-8257
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1002/mds.25623
Volume 29
Issue 1
Start page 117
End page 122
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Background: Movement disorder relapses after herpes simplex virus 1 (HSV1) encephalitis have been hypothesized to be secondary to postviral autoimmunity. Recently, a proportion of patients with HSV1 encephalitis (HSE) were shown to produce autoantibodies against N-methyl-D-aspartate receptor (NMDAR).
Methods: We measured autoantibodies against NMDAR and dopamine-2 receptor (D2R) expressed at the cell surface in the stored acute serum of 9 children with HSE, 3 of whom had a relapsing course with chorea.
Results: The 3 patients with chorea had elevated autoantibodies against NMDAR (n=1), D2R (n=1), or both (n=1), whereas patients without chorea were negative (n=6). The prospectively identified patient with chorea and NMDAR autoantibodies improved after early treatment with steroids, intravenous immunoglobulin, and cyclophosphamide, with reduction in serum NMDAR antibody titers.
Conclusions: These autoantibody findings lend support to the autoimmune hypothesis and the early use of immune suppression in post-HSE chorea.
Keyword Autoantibody
Chorea
Dopamine-2 receptor
Herpes simplex encephalitis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 1 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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