Nephron Progenitor Cells. Shifting the Balance of Self-Renewal and Differentiation.

Kopan, Raphael, Chen, Shuang and Little, Melissa (2014) Nephron Progenitor Cells. Shifting the Balance of Self-Renewal and Differentiation.. Current Topics in Developmental Biology, 107 293-331. doi:10.1016/B978-0-12-416022-4.00011-1

Author Kopan, Raphael
Chen, Shuang
Little, Melissa
Title Nephron Progenitor Cells. Shifting the Balance of Self-Renewal and Differentiation.
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
ISBN 978-0-12-416022-4
Publication date 2014-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/B978-0-12-416022-4.00011-1
Open Access Status
Volume 107
Start page 293
End page 331
Total pages 39
Editor Rendl, M
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Language eng
Subject 1307 Cell Biology
1309 Developmental Biology
Abstract Within the developing mammalian kidney, several populations of progenitors form the discrete cellular components of the final organ. Fate mapping experiments revealed the cap mesenchyme (CM) to be the progenitor population for all nephron epithelial cells, whereas the neighboring stromal mesenchyme gives rise to mesangial, pericytic, renin-producing and interstitial cells. The collecting ducts are derived from a population of progenitors at the ureteric bud (UB) tip and a proportion of the endothelium is also derived from a dedicated mesenchymal progenitor. The stroma, CM, and UB interact to create spatially defined niches at the periphery of the developing organ. While the UB tip population persist, the CM represents a transient progenitor population that is exhausted to set the final organ size. The timing of CM exhaustion, and hence the final organ structure, is sensitive to disruptions such as premature birth. Here we will discuss our current understanding of the molecular processes allowing these populations to balance cell survival, self-renewal, support of branching, and maintain capacity to commit to differentiation.
Keyword Branching
Cap mesenchyme
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DK066408
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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