Pancreatic cancer genomics

Chang, David K., Grimmond, Sean M. and Biankin, Andrew V. (2014) Pancreatic cancer genomics. Current Opinion in Genetics and Development, 24 1: 74-81. doi:10.1016/j.gde.2013.12.001

Author Chang, David K.
Grimmond, Sean M.
Biankin, Andrew V.
Title Pancreatic cancer genomics
Journal name Current Opinion in Genetics and Development   Check publisher's open access policy
ISSN 0959-437X
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.gde.2013.12.001
Open Access Status
Volume 24
Issue 1
Start page 74
End page 81
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd. * Current Opinion Journals
Language eng
Subject 1311 Genetics
1309 Developmental Biology
Abstract Pancreatic cancer is one of the most lethal malignancies. The overall median survival even with treatment is only 6-9 months, with almost 90% succumbing to the disease within a year of diagnosis. It is characterised by an intense desmoplastic stroma that may contribute to therapeutic resistance, and poses significant challenges for genomic sequencing studies. It is recalcitrant to almost all therapies and consequently remains the fourth leading cause of cancer death in Western societies. Genomic studies are unveiling a vast heterogeneity of mutated genes, and this diversity may explain why conventional clinical trial designs have mostly failed to demonstrate efficacy in unselected patients. Those that are available offer only marginal benefits overall, but are associated with clinically significant responses in as yet undefined subgroups. This chapter describes our current understanding of the genomics of pancreatic cancer and the potential impact of these findings on our approaches to treatment.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
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