Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons

Chadderton, Paul, Schaefer, Andreas T., Williams, Stephen R.  and Margrie, Troy W.  (2014) Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons. Nature Reviews Neuroscience, 15 2: 71-83. doi:10.1038/nrn3648


Author Chadderton, Paul
Schaefer, Andreas T.
Williams, Stephen R. 
Margrie, Troy W. 
Title Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons
Journal name Nature Reviews Neuroscience   Check publisher's open access policy
ISSN 1471-003X
1471-0048
Publication date 2014-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrn3648
Volume 15
Issue 2
Start page 71
End page 83
Total pages 13
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 2800 Neuroscience
Abstract Neurons integrate synaptic inputs across time and space, a process that determines the transformation of input signals into action potential output. This article explores how synaptic integration contributes to the richness of sensory signalling in the cerebellar and cerebral cortices. Whether a neuron receives a few or a few thousand discrete inputs, most evoked synaptic activity generates only subthreshold membrane potential fluctuations. Sensory tuning of synaptic inputs is typically broad, but short-term dynamics and the interplay between excitation and inhibition restrict action potential firing to narrow windows of opportunity. We highlight the challenges and limitations of the use of somatic recordings in the study of synaptic integration and the importance of active dendritic mechanisms in sensory processing.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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