Concise review: Microfluidic technology platforms: Poised to accelerate development and translation of stem cell-derived therapies

Titmarsh, Drew M., Chen, Huaying, Glass, Nick R. and Cooper-White, Justin J. (2014) Concise review: Microfluidic technology platforms: Poised to accelerate development and translation of stem cell-derived therapies. Stem Cells Translational Medicine, 3 1: 81-90. doi:10.5966/sctm.2013-0118


Author Titmarsh, Drew M.
Chen, Huaying
Glass, Nick R.
Cooper-White, Justin J.
Title Concise review: Microfluidic technology platforms: Poised to accelerate development and translation of stem cell-derived therapies
Journal name Stem Cells Translational Medicine   Check publisher's open access policy
ISSN 2157-6564
2157-6580
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.5966/sctm.2013-0118
Open Access Status DOI
Volume 3
Issue 1
Start page 81
End page 90
Total pages 10
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Language eng
Abstract Stem cells are a powerful resource for producing a variety of cell types with utility in clinically associated applications, including preclinical drug screening and development, disease and developmental modeling, and regenerative medicine. Regardless of the type of stem cell, substantial barriers to clinical translation still exist and must be overcome to realize full clinical potential. These barriers span processes including cell isolation, expansion, and differentiation; purification, quality control, and therapeutic efficacy and safety; and the economic viability of bioprocesses for production of functional cell products. Microfluidic systems have been developed for a myriad of biological applications and have the intrinsic capability of controlling and interrogating the cellular microenvironment with unrivalled precision; therefore, they have particular relevance to overcoming such barriers to translation. Development of microfluidic technologies increasingly utilizes stem cells, addresses stem cellrelevant biological phenomena, and aligns capabilities with translational challenges and goals. In this concise review, we describe how microfluidic technologies can contribute to the translation of stem cell research outcomes, and we provide an update on innovative research efforts in this area. This timely convergence of stem cell translational challenges and microfluidic capabilities means that there is now an opportunity for both disciplines to benefit from increased interaction.
Keyword Investigative techniques
Microfluidics
Stem cell research
Stem cells
Translational medical research
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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