Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion

Williams, Michael J., Clouston, Andrew D. and Forbes, Stuart J. (2014) Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Gastroenterology, 146 2: 349-356. doi:10.1053/j.gastro.2013.11.034


Author Williams, Michael J.
Clouston, Andrew D.
Forbes, Stuart J.
Title Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion
Journal name Gastroenterology   Check publisher's open access policy
ISSN 0016-5085
1528-0012
Publication date 2014-02-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1053/j.gastro.2013.11.034
Open Access Status Not Open Access
Volume 146
Issue 2
Start page 349
End page 356
Total pages 8
Place of publication Maryland Heights, United States
Publisher W.B. Saunders Co.
Language eng
Abstract Interactions between cells and their extracellular matrix have been shown to be crucial in a wide range of biological processes, including the proliferation and differentiation of stem cells. Ductular reactions containing both hepatic progenitor cells and extracellular matrix are seen in response to acute severe and chronic liver injury. Understanding the molecular mechanisms whereby cell-matrix interactions regulate liver regeneration may allow novel strategies to enhance this process. Both the ductular reaction in humans and hepatic progenitor cells in rodent models are closely associated with collagen and laminin, although there is still debate about cause and effect. Recent studies have shown a requirement for matrix remodeling by matrix metalloproteinases for the proliferation of hepatic progenitor cells and suggested defined roles for specific matrix components. Understanding the interactions between progenitor cells and matrix is critical for the development of novel regenerative and antifibrotic therapies.
Keyword Collagen
Extracellular Matrix
Laminin
Liver Regeneration
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID G0900446
G1000868
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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