The molecular biology of SRY and its role in sex determination in mammals

Koopman, P (1995) The molecular biology of SRY and its role in sex determination in mammals. Reproduction Fertility and Development, 7 4: 713-722. doi:10.1071/RD9950713


Author Koopman, P
Title The molecular biology of SRY and its role in sex determination in mammals
Journal name Reproduction Fertility and Development   Check publisher's open access policy
ISSN 1031-3613
Publication date 1995-01-01
Year available 1995
Sub-type Article (original research)
DOI 10.1071/RD9950713
Open Access Status Not yet assessed
Volume 7
Issue 4
Start page 713
End page 722
Total pages 10
Publisher C S I R O PUBLICATIONS
Language eng
Subject 1305 Biotechnology
2743 Reproductive Medicine
1312 Molecular Biology
1103 Animal Science and Zoology
1311 Genetics
1310 Endocrinology
1309 Developmental Biology
Abstract SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.
Keyword Testis-Determining Gene
Dna-Binding Motif
Determining Region
Y-Chromosome
Hmg Box
Transcription Factor
Mouse Testis
Xy-Female
Sequence
Mice
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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