Variability of oxidative stress biomarkers in hemodialysis patients

Dahwa, Rumbidzai, Fassett, Robert G., Wang, Zaimin, Briskey, David, Mallard, Alistair R. and Coombes, Jeff S. (2014) Variability of oxidative stress biomarkers in hemodialysis patients. Biomarkers, 19 2: 154-158. doi:10.3109/1354750X.2013.867533

Author Dahwa, Rumbidzai
Fassett, Robert G.
Wang, Zaimin
Briskey, David
Mallard, Alistair R.
Coombes, Jeff S.
Title Variability of oxidative stress biomarkers in hemodialysis patients
Journal name Biomarkers   Check publisher's open access policy
ISSN 1354-750x
Publication date 2014-02-13
Year available 2014
Sub-type Article (original research)
DOI 10.3109/1354750X.2013.867533
Open Access Status Not yet assessed
Volume 19
Issue 2
Start page 154
End page 158
Total pages 5
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Subject 1303 Biochemistry
1308 Clinical Biochemistry
2307 Health, Toxicology and Mutagenesis
Abstract Oxidative stress biomarkers may have a role in the future to assist clinical decisions regarding the use of antioxidant therapies and their efficacy. The aims of this study were to evaluate the within and between-individual variability of plasma oxidative stress biomarkers and investigate factors affecting their variability. Plasma F2-isoprostanes and protein carbonyls were measured in 14 hemodialysis patients every 2 weeks for 10 weeks. Within-individual coefficients of variation (CVs) were isoprostanes = 30.4% (range = 6.1–66.7%) and protein carbonyls = 16.3% (8.4–29.5%). Between-individual CVs were isoprostanes = 34.4% (28.9–40.2%) and protein carbonyls = 19.5% (15.6–24.5%). There were no significant (p > 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters.
Keyword Coefficient of variation
Index individuality
Kidney disease
Plasma isoprostanes
Protein carbonyls
Reference change value
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 14 Feb 2014, 20:41:36 EST by Zaimin Wang on behalf of Medicine - Royal Brisbane and Women's Hospital