Emerging evidence for functional peptides encoded by short open reading frames

Andrews, Shea J. and Rothnagel, Joseph A. (2014) Emerging evidence for functional peptides encoded by short open reading frames. Nature Reviews: Genetics, 15 3: 193-204. doi:10.1038/nrg3520


Author Andrews, Shea J.
Rothnagel, Joseph A.
Title Emerging evidence for functional peptides encoded by short open reading frames
Journal name Nature Reviews: Genetics   Check publisher's open access policy
ISSN 1471-0056
1471-0064
Publication date 2014-03-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrg3520
Open Access Status Not yet assessed
Volume 15
Issue 3
Start page 193
End page 204
Total pages 12
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Short open reading frames (sORFs) are a common feature of all genomes, but their coding potential has mostly been disregarded, partly because of the difficulty in determining whether these sequences are translated. Recent innovations in computing, proteomics and high-throughput analyses of translation start sites have begun to address this challenge and have identified hundreds of putative coding sORFs. The translation of some of these has been confirmed, although the contribution of their peptide products to cellular functions remains largely unknown. This Review examines this hitherto overlooked component of the proteome and considers potential roles for sORF-encoded peptides.
Formatted abstract
Short open reading frames (sORFs) are a common feature of all genomes, but their coding potential has mostly been disregarded, partly because of the difficulty in determining whether these sequences are translated. Recent innovations in computing, proteomics and high-throughput analyses of translation start sites have begun to address this challenge and have identified hundreds of putative coding sORFs. The translation of some of these has been confirmed, although the contribution of their peptide products to cellular functions remains largely unknown. This Review examines this hitherto overlooked component of the proteome and considers potential roles for sORF-encoded peptides.
Keyword Genetics & Heredity
Genetics & Heredity
GENETICS & HEREDITY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ID631551
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 118 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 126 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 14 Feb 2014, 20:36:55 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences