Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin

Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014) Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin. Biomedical Chromatography, 28 9: 1163-1166. doi:10.1002/bmc.3138


Author Bose, Utpal
Hodson, Mark P.
Shaw, P. Nicholas
Fuerst, John A.
Hewavitharana, Amitha K.
Title Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin
Journal name Biomedical Chromatography   Check publisher's open access policy
ISSN 0269-3879
1099-0801
Publication date 2014-01-29
Year available 2014
Sub-type Article (original research)
DOI 10.1002/bmc.3138
Open Access Status Not yet assessed
Volume 28
Issue 9
Start page 1163
End page 1166
Total pages 4
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Forty-five strains from two different species (Salinispora arenicola and Salinispora pacifica) were isolated from three different marine sponge species in the Great Barrier Reef region of Australia. We found that two of the strains of Salinispora arenicola (MV0335 and MV0029) produced mevinolin, a fungus-derived cholesterol-lowering agent. Compound structure was determined using an integrated approach: (a) high performance liquid chromatography-quadrupole time-of-flight-mass spectrometric analysis with multimode ionization (electrospray ionization and atmospheric pressure chemical ionization) and fast polarity switching; and (b) database searching and matching of monoisotopic masses, retention times and mass spectra of the precursor and product ions of the compounds of interest and the authentic reference standards thereof.
Keyword HPLC-UV-QToF-MS
Mevinolin
Salinispora
Sponge
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 14 Feb 2014, 19:51:54 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences