Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats

Laker, Rhianna C., Gallo, Linda A., Wlodek, Mary E., Siebel, Andrew L., Wadley, Glenn D. and McConell, Glenn K. (2011) Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats. American Journal of Physiology: Endocrinology and Metabolism, 301 5: E931-E940. doi:10.1152/ajpendo.00114.2011


Author Laker, Rhianna C.
Gallo, Linda A.
Wlodek, Mary E.
Siebel, Andrew L.
Wadley, Glenn D.
McConell, Glenn K.
Title Short-term exercise training early in life restores deficits in pancreatic β-cell mass associated with growth restriction in adult male rats
Journal name American Journal of Physiology: Endocrinology and Metabolism   Check publisher's open access policy
ISSN 0193-1849
1522-1555
Publication date 2011-11-01
Year available 2011
Sub-type Article (original research)
DOI 10.1152/ajpendo.00114.2011
Volume 301
Issue 5
Start page E931
End page E940
Total pages 10
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Formatted abstract
Fetal growth restriction is associated with reduced pancreatic β-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases β-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and β-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with sham-operated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and β-cell mass across all groups at 9 wk, partially restoring the 60–68% deficit (P < 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, β-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit (P = 0.05) in relative β-cell mass. Later exercise training also restored Restricted β-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored β-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease.
Keyword β-Cell
Fetal size
Insulin secretion
beta-Cell
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 454570
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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Created: Fri, 14 Feb 2014, 00:47:37 EST by Linda Gallo on behalf of Mater Research Institute-UQ