Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation

Weaver, Lucy G., Singh, Yogendra, Vamvounis, George, Wyatt, Mark F., Burn, Paul L. and Blanchfield, Joanne T. (2014) Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation. Polymer Chemistry, 5 4: 1173-1179. doi:10.1039/c3py01123b

Author Weaver, Lucy G.
Singh, Yogendra
Vamvounis, George
Wyatt, Mark F.
Burn, Paul L.
Blanchfield, Joanne T.
Title Carbohydrate globules: molecular asterisk-cored dendrimers for carbohydrate presentation
Journal name Polymer Chemistry   Check publisher's open access policy
ISSN 1759-9954
Publication date 2014-02-21
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c3py01123b
Open Access Status Not Open Access
Volume 5
Issue 4
Start page 1173
End page 1179
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Language eng
Formatted abstract
A convergent synthesis of a first generation dendrimer with biphenyl-based dendrons and a hexaphenylbenzene core is reported. Suzuki coupling of six first generation biphenyl-dendrons with the rigid hexakis(4-iodophenyl)benzene core furnished the title asterisk-cored dendrimer in 60% yield. Twelve copies of β-(1→6)-linked glucosamine-based oligosaccharides were then efficiently coupled with the acetylenyl surface groups of the dendrimer via a Huisgen 1,3-dipolar cycloaddition reaction to give a series of multivalent carbohydrate constructs that mimic the globular nodules of polysaccharide intercellular adhesin (PIA) produced by Staphylococcus aureus.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes First published online 23 Oct 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Centre for Organic Photonics and Electronics
Official 2014 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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Created: Thu, 13 Feb 2014, 22:20:23 EST by Joanne Blanchfield on behalf of School of Chemistry & Molecular Biosciences