Unraveling the resistance of microbial biofilms: Has proteomics been helpful?

Seneviratne, C. Jayampath, Wang, Yu, Jin, Lijian, Wong, Sarah S. W., Herath, Thanuja D. K. and Samaranayake, Lakshman P. (2012) Unraveling the resistance of microbial biofilms: Has proteomics been helpful?. Proteomics, 12 4-5: 651-665. doi:10.1002/pmic.201100356


Author Seneviratne, C. Jayampath
Wang, Yu
Jin, Lijian
Wong, Sarah S. W.
Herath, Thanuja D. K.
Samaranayake, Lakshman P.
Title Unraveling the resistance of microbial biofilms: Has proteomics been helpful?
Journal name Proteomics   Check publisher's open access policy
ISSN 1615-9853
1615-9861
Publication date 2012-02-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/pmic.201100356
Open Access Status
Volume 12
Issue 4-5
Start page 651
End page 665
Total pages 15
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 1312 Molecular Biology
1303 Specialist Studies in Education
Abstract Biofilms are surface-attached, matrix-encased, structured microbial communities which display phenotypic features that are dramatically different from those of their free-floating, or planktonic, counterparts. Biofilms seem to be the preferred mode of growth of microorganisms in nature, and at least 65% of all human infections are associated with biofilms. The most notable and clinically relevant property of biofilms is their greater resistance to antimicrobials compared with their planktonic counterparts. Although both bacterial and fungal biofilms display this phenotypic feature, the exact mechanisms underlying their increased drug resistance are yet to be determined. Advances in proteomics techniques during the past decade have facilitated in-depth analysis of the possible mechanisms underpinning increased drug resistance in biofilms. These studies have demonstrated the ability of proteomics techniques to unravel new targets for combating microbial biofilms. In this review, we discuss the putative drug resistance mechanisms of microbial biofilms that have been uncovered by proteomics and critically evaluate the possible contribution of the new knowledge to future development in the field. We also summarize strategic uses of novel proteomics technologies in studies related to drug resistance mechanisms of microbial biofilms.
Keyword Biofilm
Microbiology
Resistance
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 200907176121
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Dentistry Publications
 
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