Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species

Seneviratne, C. Jayampath, Wong, Ricky W. K. and Samaranayake, Lakshman P. (2008) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species. Mycoses, 51 1: 30-34. doi:10.1111/j.1439-0507.2007.01431.x


Author Seneviratne, C. Jayampath
Wong, Ricky W. K.
Samaranayake, Lakshman P.
Title Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species
Formatted title
Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species
Journal name Mycoses   Check publisher's open access policy
ISSN 0933-7407
1439-0507
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1111/j.1439-0507.2007.01431.x
Volume 51
Issue 1
Start page 30
End page 34
Total pages 5
Place of publication Berlin, Germany
Publisher Wiley-Blackwell
Language eng
Abstract Anti-candidial activities of eight traditional Chinese medicinal (TCM) herbs were evaluated against six different Candida species. TCM preparations were screened for antifungal activity using a standard agar diffusion assay. Following identification of potential candidate herbs, their minimum inhibitory concentration (MIC) values were determined using the standardised NCCLS M-27A broth microdilution assay. Among TCM herbs, Rhizoma Coptidis had potent antifungal activity against Candida glabrata, Candida krusei and Candida tropicalis, but not against Candida albicans, Candida dubliniensis and Candida parapsolosis. The MIC values of the Rhizoma Coptidis against C. glabrata, C. krusei and C. tropicalis were 50, 50 and 100 μg ml-1 respectively. We report here, for the first time, the potent antifungal activity of Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis and hence their possible use as therapeutic agents.
Keyword Anti-candidial activity
Candida species
Chinese medicine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes http://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2007.01431.x/pdf

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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