Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus

Tsang, C. S. P., Chu, F. C. S., Leung, W. K., Jin, L .J., Samaranayake, L. P. and Siu, S. C. (2007) Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus. Journal of Medical Microbiology, 56 10: 1393-1398. doi:10.1099/jmm.0.47303-0


Author Tsang, C. S. P.
Chu, F. C. S.
Leung, W. K.
Jin, L .J.
Samaranayake, L. P.
Siu, S. C.
Title Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus
Formatted title
Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus
Journal name Journal of Medical Microbiology   Check publisher's open access policy
ISSN 0022-2615
1473-5644
Publication date 2007-10-01
Year available 2007
Sub-type Article (original research)
DOI 10.1099/jmm.0.47303-0
Open Access Status Not yet assessed
Volume 56
Issue 10
Start page 1393
End page 1398
Total pages 6
Place of publication London, United Kingdom
Publisher The Microbiology Society
Language eng
Formatted abstract
The aim of this study was to biotype and characterize phospholipase, proteinase and haemolytic activities of oral Candida albicans isolates from 210 Chinese patients with type 2 diabetes mellitus (DM) and 210 age- and sex-matched healthy controls. Seventy-six and 50 C. albicans isolates were obtained from type 2 DM patients and controls, respectively, using the oral rinse technique. The isolates were characterized with a biotyping system based on enzyme profiles, carbohydrate assimilation patterns and boric acid resistance of the yeasts, and the isolates were further tested for in vitro phospholipase, proteinase and haemolytic activities. The major biotypes of C. albicans isolates from the type 2 DM and control groups were A1R (42.1 %) and J1R (36.0%), respectively. Significantly higher proteinase and haemolytic activities were found in the isolates from the type 2 DM group (P<0.05). Proteinase activity was higher in isolates from patients with ≥ 10 years of DM history than those with <10 years (P<0.05). Haemolytic activity was significantly higher in isolates from female DM patients than in those from male counterparts (P<0.05). These data provide evidence of increased extracellular enzyme activity in Candida isolates taken from DM patients.
Keyword Microbiology
Microbiology
MICROBIOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 49 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 57 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 19:09:06 EST by System User on behalf of Scholarly Communication and Digitisation Service