Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: a review

Tsang, C. S. P. and Samaranayake, L. P. (2010) Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: a review. Oral Diseases, 16 3: 248-256. doi:10.1111/j.1601-0825.2009.01628.x


Author Tsang, C. S. P.
Samaranayake, L. P.
Title Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: a review
Journal name Oral Diseases   Check publisher's open access policy
ISSN 1354-523X
1601-0825
Publication date 2010-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1601-0825.2009.01628.x
Volume 16
Issue 3
Start page 248
End page 256
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Language eng
Abstract The use of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV) restores immune responses against pathogens and has greatly decreased mortality. However, in about 25% to 35% of patients receiving HAART, the reconstituted immune system leads to a pathological inflammatory response, commonly known as immune reconstitution inflammatory syndrome (IRIS), which causes substantial short-term morbidity or even mortality. Although we have gleaned some knowledge on IRIS in the past few years, a number of unanswered questions remain. In this review, we discuss the definition, diagnostic criteria, pathogenesis, risk factors, clinical spectrum including oral manifestations, and management of IRIS.
Keyword AIDS
HAART
HIV
Immune reconstitution inflammatory syndrome
Oral manifestations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Dentistry Publications
 
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