Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen

Perera, R. A. P. M., Samaranayake, L. P. and Tsang, C. S. P. (2010) Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen. Archives of Oral Biology, 55 9: 639-647. doi:10.1016/j.archoralbio.2010.06.009


Author Perera, R. A. P. M.
Samaranayake, L. P.
Tsang, C. S. P.
Title Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen
Journal name Archives of Oral Biology   Check publisher's open access policy
ISSN 0003-9969
1879-1506
Publication date 2010-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.archoralbio.2010.06.009
Volume 55
Issue 9
Start page 639
End page 647
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Epstein Barr virus (EBV) is one of the ubiquitous viral carcinogens found in humans and successfully infects more than 90% of the world population. The spectrum of EBV-related pathology ranges from asymptomatic primary infection to grave B- and T-cell malignancies. EBV triggers lymphoproliferative disorders after allogeneic stem cell transplantation, which contributes to higher mortality rates. Although the transmission of EBV primarily occurs from an infected host to a naive host through viral shedding from the oropharynx, increasing evidence points to considerable amount of shedding in other anatomical sites such as cervix, anal mucosa, breast milk and respiratory tract. It is impossible to eradicate the prevalence of EBV-related malignancies and other pathologies without preventing viral shedding. However, a detail analysis of the multifaceted nature of EBV shedding is not available in the literature. Thus, this review focuses on elucidating the key elements of the shedding dynamics of this carcinogenic virus.
Keyword Carcinogen
Epstein-Barr virus
Shedding
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 18:53:07 EST by System User on behalf of School of Dentistry