Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly

Meurman, Jukka H., Parnanen, Pirjo, Seneviratne, C. Jaya, Samaranayake, Lakshman P., Saarinen, Antti M. J. and Kari, Kirsti (2011) Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly. Gerodontology, 28 4: 246-252. doi:10.1111/j.1741-2358.2010.00407.x


Author Meurman, Jukka H.
Parnanen, Pirjo
Seneviratne, C. Jaya
Samaranayake, Lakshman P.
Saarinen, Antti M. J.
Kari, Kirsti
Title Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly
Formatted title
Prevalence and antifungal drug sensitivity of non-albicans Candida in oral rinse samples of self-caring elderly
Journal name Gerodontology   Check publisher's open access policy
ISSN 0734-0664
1741-2358
Publication date 2011-01-01
Sub-type Article (original research)
DOI 10.1111/j.1741-2358.2010.00407.x
Volume 28
Issue 4
Start page 246
End page 252
Total pages 7
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Language eng
Abstract To assess the prevalence and antifungal drug sensitivity of non-albicans Candida (NAC) species in elderly outpatients. Materials and methods: We investigated oral rinse samples of 194 self-caring elderly population (mean age 83 years) with emphasis on background factors for harbouring NAC. Susceptibility of Candida species to antifungal drugs was determined using standard methodology. Multiple logistic regression analysis was performed taking positive NAC count as the dependent variable and a number of known Candida risk factors as independent variables. Results: Prevalence of candidal carriage of the population was 78.4%, of which 0.5% of the subjects were NAC positive. Candida dubliniensis was the most prevalent NAC species, followed by Candida glabrata and Candida parapsilosis. The NAC positive elderly were more often edentulous with dental prostheses or had fewer teeth than Candida albicans-positive or yeast-negative subjects. Dental caries slightly increased the risk for having NAC strains (odds ratio 1.08), whilst greater age appeared to lower the risk (odds ratio 0.77). Candida species were susceptible to the commonly used antifungal agents in general, but with considerable variation among species. Occasionally, some NAC exhibited lower antifungal susceptibility. Conclusion: The possibility of oral reservoirs of NAC strains which are resistant to common antifungals should be noted in elderly outpatients.
Keyword Elderly
Non-albicans Candida
Oral cavity
Yeasts
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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