In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species

Meurman, J. H., Kari, K., Waltimo, T., Kotiranta, A., Inkeri, J. and Samaranayake, L. P. (2006) In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species. Oral Diseases, 12 1: 45-50. doi:10.1111/j.1601-0825.2005.01156.x


Author Meurman, J. H.
Kari, K.
Waltimo, T.
Kotiranta, A.
Inkeri, J.
Samaranayake, L. P.
Title In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species
Formatted title
In vitro antifungal effect of amine fluoride-stannous fluoride combination on oral Candida species
Journal name Oral Diseases   Check publisher's open access policy
ISSN 1354-523X
1601-0825
Publication date 2006-01-01
Year available 2005
Sub-type Article (original research)
DOI 10.1111/j.1601-0825.2005.01156.x
Open Access Status Not yet assessed
Volume 12
Issue 1
Start page 45
End page 50
Total pages 6
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective: The combination of amine fluoride and stannous fluoride (AmF/SnF2) was, by chance, found to be antifungal in a clinical trial. This study investigated its effect on pathogenic Candida species with the hypothesis that the antifungal action on different species is variable.

Materials and methods: Growth inhibition effect of Meridol® mouth rinse which contains 250 ppm AmF/SnF2 was evaluated on 43 reference and clinical strains of Candida albicans, C. dubliniensis, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis, and C. tropicalis. Meridol® base solution without AmF/SnF2 was used as a negative control.

Results: Undiluted Meridol® mouth rinse killed most study strains within a few minutes. In ascending order, C. parapsilosis, C. tropicalis, C. albicans, C. glabrata, C. krusei and C. dubliniensis showed higher resistance against AmF/SnF2 than C. guilliermondii.

Conclusion: AmF/SnF2 could be used as a potent adjunct to antifungal therapy for oral yeasts. Although different Candida species demonstrated variable sensitivity the most prevalent oral yeast C. albicans appeared sensitive to the AmF/SnF2 combination.
Keyword Amine fluoride
Antifungal effect
Candida albicans
Candida dubliniensis
Candida glabrata
Candida guilliermondii
Candida krusei
Candida parapsilosis
Candida tropicalis
Stannous fluoride
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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