Wet cough in children: Infective and inflammatory characteristics in broncho-alveolar lavage fluid

Wurzel, D.F., Marchant, J.M., Clark, J.E., Masters, I.B., Yerkovich, S.T., Upham, J.W. and Chang, A.B. (2013) Wet cough in children: Infective and inflammatory characteristics in broncho-alveolar lavage fluid. Pediatric Pulmonology, 49 6: 561-568. doi:10.1002/ppul.22792


Author Wurzel, D.F.
Marchant, J.M.
Clark, J.E.
Masters, I.B.
Yerkovich, S.T.
Upham, J.W.
Chang, A.B.
Title Wet cough in children: Infective and inflammatory characteristics in broncho-alveolar lavage fluid
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
1099-0496
Publication date 2013-01-01
Year available 2014
Sub-type Article (original research)
DOI 10.1002/ppul.22792
Open Access Status Not yet assessed
Volume 49
Issue 6
Start page 561
End page 568
Total pages 8
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons, Inc.
Language eng
Abstract Wet cough is a common feature of many disease processes affecting children. Our aim was to examine the relationships between cough nature, lower airway infection (bacterial, viral, and viral-bacterial) and severity of neutrophilic airway inflammation. We hypothesized that viral-bacterial co-infection of the lower airway would be associated with wet cough and heightened neutrophilic airway inflammation. We prospectively recruited 232 children undergoing elective flexible bronchoscopy. Participants were grouped using a cough nature symptom-based approach, into wet, dry or no cough groups. Broncho-alveolar lavage (BAL) and clinical data, including presence, nature, and duration of cough and key demographic factors, were collected. Children with wet cough (n=143) were more likely to have lower airway bacterial infection (OR 2.6, P=0.001), viral infection (OR 2.04, P=0.045) and viral-bacterial co-infection (OR 2.65, P=0.042) compared to those without wet cough. Wet cough was associated with heightened airway neutrophilia (median 19%) as compared to dry or no cough. Viral-bacterial co-infection was associated with the highest median %neutrophils (33.5%) compared to bacteria only, virus/es only and no infection (20%, 18%, and 6%, respectively, P<0.0001). Children with wet cough had higher rates of lower airway infection with bacteria and viruses. Maximal neutrophilic airway inflammation was seen in those with viral-bacterial co-infection. Cough nature may be a useful indicator of infection and inflammation of the lower airways in children. Pediatr Pulmonol. 2014; 49:561-568. (c) 2013 Wiley Periodicals, Inc.
Keyword Pediatrics
Respiratory System
Pediatrics
Respiratory System
PEDIATRICS
RESPIRATORY SYSTEM
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID GNT1039688
545216
Institutional Status UQ
Additional Notes Article first published online: 20 JUN 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Queensland Children's Medical Research Institute Publications
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 12 Feb 2014, 18:29:11 EST by Matthew Lamb on behalf of School of Medicine