Adhesion of Candida parapsilosis to epithelial and acrylic surfaces correlates with cell surface hydrophobicity

Panagoda, G. J., Ellepola, A. N. B. and Samaranayake, L. P. (2001) Adhesion of Candida parapsilosis to epithelial and acrylic surfaces correlates with cell surface hydrophobicity. Mycoses, 44 1-2: 29-35. doi:10.1046/j.1439-0507.2001.00611.x


Author Panagoda, G. J.
Ellepola, A. N. B.
Samaranayake, L. P.
Title Adhesion of Candida parapsilosis to epithelial and acrylic surfaces correlates with cell surface hydrophobicity
Formatted title
Adhesion of Candida parapsilosis to epithelial and acrylic surfaces correlates with cell surface hydrophobicity
Journal name Mycoses   Check publisher's open access policy
ISSN 0933-7407
1439-0507
Publication date 2001-03-01
Year available 2001
Sub-type Article (original research)
DOI 10.1046/j.1439-0507.2001.00611.x
Open Access Status Not yet assessed
Volume 44
Issue 1-2
Start page 29
End page 35
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
We investigated in vitro adherence of 24 isolates of Candida parapsilosis and 12 isolates of Candida albicans with regard to their relative cell-surface hydrophobicity (CSH), adherence to human buccal epithelial cells (BEC) and acrylic surfaces. There was no significant interspecies difference in the relative adherence of C. parapsilosis and C. albicans isolates to BEC, although the former demonstrated a tendency for increased adherence. However, a significant intra-species variation in adherence among isolates of C. parapsilosis (P<0.0001) to BEC, but not of C. albicans was noted. The superficial isolates of C. parapsilosis demonstrated a higher avidity (33%) to BEC than the systemic isolates. On regression analysis a significant positive correlation between C. parapsilosis adherence to BEC and denture acrylic surfaces was noted (r=0.45, P=0.02). Similarly, buccal cell adherence correlated strongly with CSH of C. parapsilosis (r=0.63, P=0.0008). These results shed further light on the intimate relationship between adherence and CSH in candidal colonization and imply that both C. parapsilosis and C. albicans are equally potent in colonizing mucosal surfaces with respect to the attributes investigated.
Keyword Adherence
Candida albicans
Candida parapsilosis
Hydrophobicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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