The role of salivary factors in persistent oral carriage of Candida in humans

Hibino, Kyoko, Samaranayake, Lakshman P., Hagg, Urban, Wong, Ricky W. K. and Lee, Wilson (2009) The role of salivary factors in persistent oral carriage of Candida in humans. Archives of Oral Biology, 54 7: 678-683. doi:10.1016/j.archoralbio.2009.04.003


Author Hibino, Kyoko
Samaranayake, Lakshman P.
Hagg, Urban
Wong, Ricky W. K.
Lee, Wilson
Title The role of salivary factors in persistent oral carriage of Candida in humans
Journal name Archives of Oral Biology   Check publisher's open access policy
ISSN 0003-9969
1879-1506
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.archoralbio.2009.04.003
Volume 54
Issue 7
Start page 678
End page 683
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 2733 Otorhinolaryngology
1307 Cell Biology
3500 Dentistry
Abstract Background: Candida albicans is a commensal oral yeast in approximately one-third to one-half of the healthy population. To date, there are no studies investigating the multiple anti-candidal salivary constituents of healthy individuals with either nil or, consistent oral yeast carriage. Objective: To compare the composition and anti-candidal activity in stimulated whole saliva of healthy 'consistent' oral Candida carriers with Candida-free individuals. Methods: A sub-sample of 22 consistent, Candida-free individuals and 10 consistent Candida carriers were recruited from a 12 months screening study investigating oral Candida carriage in 97 healthy patients treated by fixed orthodontic appliances. Unstimulated and stimulated saliva samples were collected. The following salivary attributes were measured using standard methodology: the flow rate, pH, lysozyme, lactoferrin and IgA concentration and, the degree of inhibition of blastoconidial growth and blastospore germination. Results: Saliva from the Candida-free individuals showed 20.2% higher inhibition of blastoconidial growth (p < 0.05) of a reference strain of Candida albicans. No significant differences between the other salivary attributes of the two groups were found. Conclusion: The fact that saliva of Candida-free individuals significantly inhibited the blastoconidial growth more than Candida-carriers (p < 0.05) suggests that saliva may play a role in modulating oral candidal populations in health. Further studies, with a larger cohort are needed to confirm these findings and determine the factors that confer enhanced salivary anti-candidal activity.
Keyword Anti candidal activity
Anti candidal salivary factors
Candida carriers and non carriers
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 7624/06M
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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