Frequent allelic loss of 21q11.1∼q21.1 region in advanced stage oral squamous cell carcinoma

Chen, Lan, Wong, Maria Pik, Cheung, Lim Kwong, Samaranayake, Lakshman P., Baum, Larry and Samman, Nabil (2005) Frequent allelic loss of 21q11.1∼q21.1 region in advanced stage oral squamous cell carcinoma. Cancer Genetics and Cytogenetics, 159 1: 37-43. doi:10.1016/j.cancergencyto.2004.09.011


Author Chen, Lan
Wong, Maria Pik
Cheung, Lim Kwong
Samaranayake, Lakshman P.
Baum, Larry
Samman, Nabil
Title Frequent allelic loss of 21q11.1∼q21.1 region in advanced stage oral squamous cell carcinoma
Journal name Cancer Genetics and Cytogenetics   Check publisher's open access policy
ISSN 0165-4608
2210-7770
Publication date 2005-05-01
Sub-type Article (original research)
DOI 10.1016/j.cancergencyto.2004.09.011
Open Access Status Not yet assessed
Volume 159
Issue 1
Start page 37
End page 43
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
A fine mapping of loss of heterozygosity (LOH) was performed in oral squamous cell carcinoma (OSCC), using 12 markers on 21q11.1∼q21.1. We studied 43 resected primary invasive tumors and their paired normal tissues, concurrent dysplasia or carcinoma in situ in separate areas from 8 of the specimens, and 6 local recurrent carcinomas. LOH status was compared between lesions of different phases of progression within the same patient. A high frequency of LOH was observed for D21S1410, D21S120, and D21S1433 (60% each) in the primary lesions, constituting two interstitial deleted regions encompassing eight known genes. Cases showing LOH of D21S120 were significantly associated with advanced clinical stages (III and IV; P = 0.02). Consistent allelic loss was observed in 64.2% of the informative cases between the precursor lesions and their corresponding invasive tumors, and in 59.5% of those between the primary lesions and their recurrent counterparts. Fewer than half of the different lesions within a given patient showed discordant allelic loss for tested markers. Our results suggest that 21q11.1∼q21.1 harbors tumor suppressor genes in OSCC. Genetic divergence may develop during tumor clone evolution.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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