Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke

Baboni, Fernanda Brasil, Barp, Dayton, Santos de Azevedo Izidoro, Ana Claudia, Samaranayake, Lakshman Perera and Rosa, Edvaldo Antonio Ribeiro (2009) Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke. Mycopathologia, 168 5: 227-235. doi:10.1007/s11046-009-9217-5


Author Baboni, Fernanda Brasil
Barp, Dayton
Santos de Azevedo Izidoro, Ana Claudia
Samaranayake, Lakshman Perera
Rosa, Edvaldo Antonio Ribeiro
Title Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke
Formatted title
Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke 
Journal name Mycopathologia   Check publisher's open access policy
ISSN 0301-486X
1573-0832
Publication date 2009-01-01
Sub-type Article (original research)
DOI 10.1007/s11046-009-9217-5
Volume 168
Issue 5
Start page 227
End page 235
Total pages 9
Place of publication Dordrecht, Netherlands
Publisher Springer
Language eng
Abstract The habit of cigarette smoking is associated with higher oral candidal carriage and possible predisposition to oral candidosis. The effects of exposure to smoke on the virulence properties of oral yeasts remain obscure. Hence, we showed in vitro the effect of cigarette smoke condensate (CSC) on ten clinical isolates of Candida albicans obtained from nonsmoking volunteers, as well the type-strain CBS562. CSC was generated by complete burn of five commercial cigarettes in an in-house smoking machine and used to prepare the culture broth in which the strains were grown. In 24-h intervals (T24, T48, and T72), the cells were harvested, washed, subcultured, and the resultant growth were evaluated for possible variations for secreted aspartyl protease, phospholipase, chondroitinase, and hemolysins, adhesion to acrylic and cell surface hydrophobicity (CSH). The results indicated a temporal increase in the secretion rates of enzymes, particularly when yeast cells were exposed to CSC for 48-72h (P < 0.05). Similarly, adhesion to acrylic and CSH increased with exposure period (P < 0.05). Based on foregoing, we concluded that CSC may promote significant enhance in the secretion of candidal histolytic enzymes and adherence to denture surfaces, thereby promoting oral yeast carriage and possible infection.
Keyword Candida albicans
Cigarette smoke
Virulence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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