High tidal volume ventilation does not exacerbate acid-induced lung injury in infant rats

Sly, P.D., Nicholls, P.K., Berry, L.J., Hantos, Z. and Cannizzaro, V. (2013) High tidal volume ventilation does not exacerbate acid-induced lung injury in infant rats. Respiratory Physiology and Neurobiology, 189 1: 129-135. doi:10.1016/j.resp.2013.07.013

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Author Sly, P.D.
Nicholls, P.K.
Berry, L.J.
Hantos, Z.
Cannizzaro, V.
Title High tidal volume ventilation does not exacerbate acid-induced lung injury in infant rats
Journal name Respiratory Physiology and Neurobiology   Check publisher's open access policy
ISSN 1569-9048
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.resp.2013.07.013
Open Access Status DOI
Volume 189
Issue 1
Start page 129
End page 135
Total pages 7
Place of publication Amsterdam, AE, Netherlands
Publisher Elsevier BV
Language eng
Subject 1314 Physiology
2740 Pulmonary and Respiratory Medicine
2800 Neuroscience
Abstract The impact of mechanical ventilation with high VT-low PEEP in infant rats with preinjured lungs is unknown. After tracheal instillation of saline or acid, two week old rats were ventilated with VT 7mL/kg and PEEP 5cm H2O or VT 21mL/kg and PEEP 1cm H2O for 4h. Airway resistance and the coefficient of tissue elastance, measured via low-frequency forced-oscillation technique, and quasi-static pressure-volume curves deteriorated less with high VT-low PEEP when compared with low VT-high PEEP. IL-6 concentration in bronchoalveolar lavage fluid (BALF) did not differ between all ventilated groups. Moreover, differences in BALF protein concentration and histological lung injury scores were independent of applied ventilation strategies. In contrast to experimental studies with adult rats, short-term mechanical ventilation with high VT-low PEEP is not deleterious when compared to low VT-high PEEP in both healthy and pre-injured infant rat lungs. Our results call for caution when extrapolating data from adult studies and highlight the need for age-specific animal models.
Keyword Forced oscillation technique
Mechanical ventilation
Positive end-expiratory pressure
Respiratory system mechanics
Tidal volume
Ventilator-induced lung injury
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 35
Institutional Status UQ

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Created: Wed, 12 Feb 2014, 17:49:42 EST by Matthew Lamb on behalf of School of Medicine