The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?

Pessia, Eugénie, Engelstaedter, Jan and Marais, Gabriel A. B. (2014) The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?. Cellular and Molecular Life Sciences, 71 8: 1383-1394. doi:10.1007/s00018-013-1499-6

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Author Pessia, Eugénie
Engelstaedter, Jan
Marais, Gabriel A. B.
Title The evolution of X chromosome inactivation in mammals: the demise of Ohno's hypothesis?
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
1420-9071
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00018-013-1499-6
Open Access Status
Volume 71
Issue 8
Start page 1383
End page 1394
Total pages 12
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Language eng
Formatted abstract
Ohno’s hypothesis states that dosage compensation in mammals evolved in two steps: a twofold hyperactivation of the X chromosome in both sexes to compensate for gene losses on the Y chromosome, and silencing of one X (X-chromosome inactivation, XCI) in females to restore optimal dosage. Recent tests of this hypothesis have returned contradictory results. In this review, we explain this ongoing controversy and argue that a novel view on dosage compensation evolution in mammals is starting to emerge. Ohno’s hypothesis may be true for a few, dosage-sensitive genes only. If so few genes are compensated, then why has XCI evolved as a chromosome-wide mechanism? This and several other questions raised by the new data in mammals are discussed, and future research directions are proposed.
Keyword Sex chromosomes
Sex determination
Dosage compensation
Dosage-sensitive genes
Parental antagonism model
RNAseq data
2R hypothesis
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ANR-12-BSV7-0002
Institutional Status UQ
Additional Notes Published online: 31 October 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biological Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Wed, 12 Feb 2014, 01:06:38 EST by Gail Walter on behalf of School of Biological Sciences