Sex disparities in risk and risk factors for ischemic heart disease in the Asia-Pacific region

Peters, Sanne A. E., Woodward, Mark, Lam, Tai H., Fang, Xianghua, Suh, Il, Ueshema, Hirotsugu, Dobson, Annette J., Grobbee, Diederick E. and Huxley, Rachel R. (2013) Sex disparities in risk and risk factors for ischemic heart disease in the Asia-Pacific region. European Journal of Preventive Cardiology, OnlineFirst 5: 1-8. doi:10.1177/2047487313484689

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Author Peters, Sanne A. E.
Woodward, Mark
Lam, Tai H.
Fang, Xianghua
Suh, Il
Ueshema, Hirotsugu
Dobson, Annette J.
Grobbee, Diederick E.
Huxley, Rachel R.
Title Sex disparities in risk and risk factors for ischemic heart disease in the Asia-Pacific region
Journal name European Journal of Preventive Cardiology   Check publisher's open access policy
ISSN 2047-4873
Publication date 2013-03-27
Year available 2013
Sub-type Article (original research)
DOI 10.1177/2047487313484689
Volume OnlineFirst
Issue 5
Start page 1
End page 8
Total pages 8
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Formatted abstract
Background Ischemic heart disease (IHD) is the leading cause of death and disability worldwide, with higher rates among men than women. Relatively few studies on risk factor associations are available from the Asia-Pacific region, especially with regard to sex differences. Our objective was to compare the relationships between modifiable risk factors and IHD in men and women from the Asia-Pacific region.

Methods Data from 600,445 individuals from 44 studies from the Asia Pacific Cohort Studies Collaboration, an individual patient data overview, were used. Cox models were used to evaluate the effects of risk factors on fatal and non-fatal IHD separately in men and women from Australia and New Zealand (ANZ) and Asia.

Results Over a median follow-up of 6.7 years, 5695 IHD events were documented. The hazard ratio for IHD, comparing men with women, was 2.14 (95% CI 1.97–2.33) in ANZ and 1.88 (95% CI 1.54–2.29) in Asia. The age-adjusted prevalence of major risk factors was generally higher in men than women, especially in ANZ. Risk factors acted broadly similarly between men and women in both Asia and ANZ, with any indications of differences tending to favor men, rather than women.

Conclusion The excess risk of IHD observed in men compared with women in both Asia and ANZ may be, at least in part, a result of a more hazardous risk profile in men compared with women. The contribution of sex differences in the magnitude of the risk factor–disease associations is unlikely to be a contributing factor.
Keyword Ischemic heart disease
Risk factors
Sex differences
Asia-Pacific region
Global health
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print March 27, 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 10 Feb 2014, 21:33:39 EST by Katherine De Maria on behalf of School of Public Health