Animal studies on medicinal herbs: predictability, dose conversion and potential value

Wojcikowski, Ken and Gobe, Glenda (2014) Animal studies on medicinal herbs: predictability, dose conversion and potential value. Phytotherapy Research, 28 1: 22-27. doi:10.1002/ptr.4966


Author Wojcikowski, Ken
Gobe, Glenda
Title Animal studies on medicinal herbs: predictability, dose conversion and potential value
Journal name Phytotherapy Research   Check publisher's open access policy
ISSN 0951-418X
1099-1573
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ptr.4966
Open Access Status
Volume 28
Issue 1
Start page 22
End page 27
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Animal studies testing medicinal herbs are often misinterpreted by both translational researchers and clinicians due to a lack of information regarding their predictability, human dose equivalent and potential value. The most common mistake is to design or translate an animal study on a milligram per kilogram basis. This can lead to underestimation of the toxicity and/or overestimation of the amount needed for human therapy. Instead, allometric scaling, which involves body surface area, should be used. While the differences in the pharmacokinetic and pharmacodynamic phases between species will inevitably lead to some degree of error in extrapolation of results regardless of the conversion method used, correct design and interpretation of animal studies can provide information that is not able to be provided by in vitro studies, computer modeling or even traditional use. Copyright
Keyword Allometric scaling
Conversion
Correlation
Dose translation
Equivalent
Medicinal herbs
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 09 Feb 2014, 10:15:34 EST by System User on behalf of School of Medicine