Late replication domains are evolutionary conserved in the Drosophila genome

Andreyenkova, Natalya G., Kolesnikova, Tatyana D., Makunin, Igor V., Pokholkova, Galina V., Boldyreva, Lidiya V., Zykova, Tatyana Yu., Zhimulev, Igor F. and Belyaeva, Elena S. (2013) Late replication domains are evolutionary conserved in the Drosophila genome. PloS One, 8 12: . doi:10.1371/journal.pone.0083319


Author Andreyenkova, Natalya G.
Kolesnikova, Tatyana D.
Makunin, Igor V.
Pokholkova, Galina V.
Boldyreva, Lidiya V.
Zykova, Tatyana Yu.
Zhimulev, Igor F.
Belyaeva, Elena S.
Title Late replication domains are evolutionary conserved in the Drosophila genome
Formatted title
Late replication domains are evolutionary conserved in the Drosophila genome
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-12-31
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0083319
Open Access Status DOI
Volume 8
Issue 12
Total pages 12
Place of publication San Francisco, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Drosophila chromosomes are organized into distinct domains differing in their predominant chromatin composition, replication timing and evolutionary conservation. We show on a genome-wide level that genes whose order has remained unaltered across 9 Drosophila species display late replication timing and frequently map to the regions of repressive chromatin. This observation is consistent with the existence of extensive domains of repressive chromatin that replicate extremely late and have conserved gene order in the Drosophila genome. We suggest that such repressive chromatin domains correspond to a handful of regions that complete replication at the very end of S phase. We further demonstrate that the order of genes in these regions is rarely altered in evolution. Substantial proportion of such regions significantly coincide with large synteny blocks. This indicates that there are evolutionary mechanisms maintaining the integrity of these late-replicating chromatin domains. The synteny blocks corresponding to the extremely late-replicating regions in the D. melanogaster genome consistently display two-fold lower gene density across different Drosophila species.
Keyword Melanogaster polytene chromosomes
Human comparative map
Intercalary heterochromatin
DNA underreplication
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e83319

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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