Are there any benefits from statin treatment for the septic patient?

Kruger, P.S. and Venkatesh, B. (2014) Are there any benefits from statin treatment for the septic patient?. Current Atherosclerosis Reports, 16 1: 1-8. doi:10.1007/s11883-013-0378-9


Author Kruger, P.S.
Venkatesh, B.
Title Are there any benefits from statin treatment for the septic patient?
Journal name Current Atherosclerosis Reports   Check publisher's open access policy
ISSN 1523-3804
1534-6242
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s11883-013-0378-9
Volume 16
Issue 1
Start page 1
End page 8
Total pages 8
Place of publication Philadelphia, PA, U.S.A.
Publisher Springer Healthcare
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Statins have become the most widely used drugs for lowering cholesterol levels worldwide. At least 20 % of patients requiring admission to hospital are on established statin therapy, and this proportion is growing each year. Evidence from observational studies and basic science research suggests that statins might be associated with a reduced mortality in sepsis. Randomized trials are producing equivocal results but have not shown the marked improvement in outcome suggested by the observational studies. Continued use in current statin users appears a more fruitful area for future research than statin use de novo as an adjuvant therapy in sepsis. Statin use in patients with pneumonia, acute lung injury or early sepsis warrants further study. International practice of statin use in critically ill patients is variable, and potential toxicity mandates careful monitoring. Further studies are required to address fundamental issues such as efficacy, potential target patient populations, dose, class equivalence and safety.
Keyword HMCoA reductase inhibitor
Sepsis
Statin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 26 November 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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