Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu and Xu, Zhi P. (2014) Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. Biomaterials, 35 10: 3331-3339. doi:10.1016/j.biomaterials.2013.12.095

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Author Li, Li
Gu, Wenyi
Chen, Jiezhong
Chen, Weiyu
Xu, Zhi P.
Title Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2014-03-01
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2013.12.095
Volume 35
Issue 10
Start page 3331
End page 3339
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.
Keyword Co-delivery system
Layered double hydroxide
Electrostatic assembly
Apoptosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 04 Feb 2014, 23:48:54 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology