Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles

Li, Li, Gu, Wenyi, Chen, Jiezhong, Chen, Weiyu and Xu, Zhi P. (2014) Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. Biomaterials, 35 10: 3331-3339. doi:10.1016/j.biomaterials.2013.12.095

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Author Li, Li
Gu, Wenyi
Chen, Jiezhong
Chen, Weiyu
Xu, Zhi P.
Title Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
1878-5905
Publication date 2014-03-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2013.12.095
Open Access Status Not yet assessed
Volume 35
Issue 10
Start page 3331
End page 3339
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1502 Bioengineering
2503 Ceramics and Composites
1304 Biophysics
2502 Biomaterials
2211 Mechanics of Materials
Abstract In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.
Formatted abstract
In this research we employed layered double hydroxide nanoparticles (LDHs) to simultaneously deliver an anticancer drug 5-fluorouracil (5-FU) and Allstars Cell Death siRNA (CD-siRNA) for effective cancer treatment. The strategy takes advantage of the LDH anion exchange capacity to intercalate 5-FU into its interlayer spacing and load siRNA on the surface of LDH nanoparticles. LDH nanoparticles have been previously demonstrated as an effective cellular delivery system for 5-FU and siRNA separately in various investigations. More excitedly, the combination of CD-siRNA and anticancer drug 5-FU with the same LDH particles significantly enhanced cytotoxicity to three cancer cell lines, e.g. MCF-7, U2OS and HCT-116, compared to the single treatment with either CD-siRNA or 5-FU. This enhancement is probably a result of coordinate mitochondrial damage process. Thus, the strategy to co-deliver siRNA and an anticancer drug by LDHs has great potential to overcome the drug resistance and enhance cancer treatment.
Keyword Co-delivery system
Layered double hydroxide
Electrostatic assembly
Apoptosis
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID FT120100813
DP120104792
Institutional Status UQ

 
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Created: Tue, 04 Feb 2014, 23:48:54 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology