Prevention and treatment of acute radiation induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

Chan, Raymond Javan, Webster, Joan, Chung, Bryan, Marquart, Louise, Ahmed, Muhtashimuddin and Garantziotis, Stuart (2014) Prevention and treatment of acute radiation induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer, 14 53: 1-19. doi:10.1186/1471-2407-14-53

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Author Chan, Raymond Javan
Webster, Joan
Chung, Bryan
Marquart, Louise
Ahmed, Muhtashimuddin
Garantziotis, Stuart
Title Prevention and treatment of acute radiation induced skin reactions: a systematic review and meta-analysis of randomized controlled trials
Journal name BMC Cancer   Check publisher's open access policy
ISSN 1471-2407
Publication date 2014-01-31
Year available 2014
Sub-type Article (original research)
DOI 10.1186/1471-2407-14-53
Open Access Status DOI
Volume 14
Issue 53
Start page 1
End page 19
Total pages 19
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background Radiation-induced skin reaction (RISR) is a common side effect that affects the majority of cancer patients receiving radiation treatment. RISR is often characterised by swelling, redness, pigmentation, fibrosis, and ulceration, pain, warmth, burning, and itching of the skin. The aim of this systematic review was to assess the effects of interventions which aim to prevent or manage RISR in people with cancer.

Methods We searched the following databases up to November 2012: Cochrane Skin Group Specialised Register, CENTRAL (2012, Issue 11), MEDLINE (from 1946), EMBASE (from 1974), PsycINFO (from 1806), CINAHL (from 1981) and LILACS (from 1982). Randomized controlled trials evaluating interventions for preventing or managing RISR in cancer patients were included. The primary outcomes were development of RISR, and levels of RISR and symptom severity. Secondary outcomes were time taken to develop erythema or dry desquamation; quality of life; time taken to heal, a number of skin reaction and symptom severity measures; cost, participant satisfaction; ease of use and adverse effects. Where appropriate, we pooled results of randomized controlled trials using mean differences (MD) or odd ratios (OR) with 95% confidence intervals (CI).

Results Forty-seven studies were included in this review. These evaluated six types of interventions (oral systemic medications; skin care practices; steroidal topical therapies; non-steroidal topical therapies; dressings and other). Findings from two meta-analyses demonstrated significant benefits of oral Wobe-Mugos E for preventing RISR (OR 0.13 (95% CI 0.05 to 0.38)) and limiting the maximal level of RISR (MD -0.92 (95% CI -1.36 to -0.48)). Another meta-analysis reported that wearing deodorant does not influence the development of RISR (OR 0.80 (95% CI 0.47 to 1.37)).

Conclusions Despite the high number of trials in this area, there is limited good, comparative research that provides definitive results suggesting the effectiveness of any single intervention for reducing RISR. More research is required to demonstrate the usefulness of a wide range of products that are being used for reducing RISR. Future efforts for reducing RISR severity should focus on promising interventions, such as Wobe-Mugos E and oral zinc.
Keyword Radiation induced skin reactions
Radiation dermatitis
Systematic review
Meta analysis
Randomized controlled trials
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Nursing, Midwifery and Social Work Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 25 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 04 Feb 2014, 21:02:54 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work