Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease

Nath, K.D., Burel, J.G., Shankar, V., Pritchard, A.L., Towers, M., Looke, D., Davies, J.M. and Upham, J.W. (2013) Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease. International Journal of COPD, 9 51-56. doi:10.2147/COPD.S53590


Author Nath, K.D.
Burel, J.G.
Shankar, V.
Pritchard, A.L.
Towers, M.
Looke, D.
Davies, J.M.
Upham, J.W.
Title Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease
Journal name International Journal of COPD   Check publisher's open access policy
ISSN 1176-9106
1178-2005
Publication date 2013-12-24
Sub-type Article (original research)
DOI 10.2147/COPD.S53590
Open Access Status DOI
Volume 9
Start page 51
End page 56
Total pages 6
Place of publication Auckland, New Zealand
Publisher Dove Medical Press Ltd.
Language eng
Subject 2740 Pulmonary and Respiratory Medicine
2739 Public Health, Environmental and Occupational Health
2719 Health Policy
Abstract Background and objective: Individuals with chronic obstructive pulmonary disease (COPD) are at a high risk of developing signifcant complications from infection with the influenza virus. It is therefore vital to ensure that prophylaxis with the influenza vaccine is effective in COPD. The aim of this study was to assess the immunogenicity of the 2010 trivalent influenza vaccine in persons with COPD compared to healthy subjects without lung disease, and to examine clinical factors associated with the serological response to the vaccine. Methods: In this observational study, 34 subjects (20 COPD, 14 healthy) received the 2010 infu-enza vaccine. Antibody titers at baseline and 28 days post-vaccination were measured using the hemagglutination inhibition assay (HAI) assay. Primary endpoints included seroconversion ($4-fold increase in antibody titers from baseline) and the fold increase in antibody titer after vaccination. Results: Persons with COPD mounted a significantly lower humoral immune response to the infuenza vaccine compared to healthy participants. Seroconversion occurred in 90% of healthy participants, but only in 43% of COPD patients (P=0.036). Increasing age and previous influ-enza vaccination were associated with lower antibody responses. Antibody titers did not vary significantly with cigarette smoking, presence of other comorbid diseases, or COPD severity. Conclusion: The humoral immune response to the 2010 influenza vaccine was lower in persons with COPD compared to non-COPD controls. The antibody response also declined with increasing age and in those with a history of prior vaccination.
Keyword COPD
Human infuenza
Humoral immunity
Infuenza vaccines
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
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