Calcium influx pathways in breast cancer: opportunities for pharmacological intervention

Azimi, I., Roberts-Thomson, S. J. and Monteith, G. R. (2014) Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. British Journal of Pharmacology, 171 4: 945-960. doi:10.1111/bph.12486

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Author Azimi, I.
Roberts-Thomson, S. J.
Monteith, G. R.
Title Calcium influx pathways in breast cancer: opportunities for pharmacological intervention
Journal name British Journal of Pharmacology   Check publisher's open access policy
ISSN 0007-1188
1476-5381
Publication date 2014-02-01
Year available 2014
Sub-type Article (original research)
DOI 10.1111/bph.12486
Open Access Status Not yet assessed
Volume 171
Issue 4
Start page 945
End page 960
Total pages 16
Editor Phil Beart
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx is also a regulator of processes relevant to cancer, including cellular proliferation and migration. This review focuses on calcium influx in breast cancer cells as well as the potential for pharmacological modulators of specific Ca2+ influx channels to represent future agents for breast cancer therapy. Altered expression of specific calcium permeable ion channels is present in some breast cancers. In some cases, such changes can be related to breast cancer subtype and even prognosis. In vitro and in vivo models have now helped identify specific Ca2+ channels that play important roles in the proliferation and invasiveness of breast cancer cells. However, some aspects of our understanding of Ca2+ influx in breast cancer still require further study. These include identifying the mechanisms responsible for altered expression and the most effective therapeutic strategy to target breast cancer cells through specific Ca2+ channels. The role of Ca2+ influx in processes beyond breast cancer cell proliferation and migration should become the focus of studies in the next decade.
Formatted abstract
Ca2+ influx through Ca2+ permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle contraction. Ca2+ influx is also a regulator of processes relevant to cancer, including cellular proliferation and migration. This review focuses on calcium influx in breast cancer cells as well as the potential for pharmacological modulators of specific Ca2+ influx channels to represent future agents for breast cancer therapy. Altered expression of specific calcium permeable ion channels is present in some breast cancers. In some cases, such changes can be related to breast cancer subtype and even prognosis. In vitro and in vivo models have now helped identify specific Ca2+ channels that play important roles in the proliferation and invasiveness of breast cancer cells. However, some aspects of our understanding of Ca2+ influx in breast cancer still require further study. These include identifying the mechanisms responsible for altered expression and the most effective therapeutic strategy to target breast cancer cells through specific Ca2+ channels. The role of Ca2+ influx in processes beyond breast cancer cell proliferation and migration should become the focus of studies in the next decade.
Keyword Breast cancer
Calcium channels
Calcium influx
Calcium signalling
Oncology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 569645
1042819
Institutional Status UQ
Additional Notes http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925034/

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Pharmacy Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 41 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 03 Feb 2014, 21:40:23 EST by Charna Kovacevic on behalf of School of Pharmacy