CD300 molecule regulation of human dendritic cell functions

Gasiorowski, R. E., Ju, X., Hart, D. N. J. and Clark, G. J. (2013) CD300 molecule regulation of human dendritic cell functions. Immunology Letters, 149 1-2: 93-100. doi:10.1016/j.imlet.2012.10.005

Author Gasiorowski, R. E.
Ju, X.
Hart, D. N. J.
Clark, G. J.
Title CD300 molecule regulation of human dendritic cell functions
Journal name Immunology Letters   Check publisher's open access policy
ISSN 0165-2478
Publication date 2013-01-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.imlet.2012.10.005
Open Access Status Not yet assessed
Volume 149
Issue 1-2
Start page 93
End page 100
Total pages 8
Place of publication Amsterdam, AE, Netherlands
Publisher Elsevier
Language eng
Subject 2403 Immunology
2723 Immunology and Allergy
Abstract Dendritic cells (DC) are a heterogeneous population of leucocytes which play a key role in initiating and modulating immune responses. The human CD300 family consists of six immunoregulatory leucocyte membrane molecules that regulate cellular activity including differentiation, viability, cytokine and chemokine secretion, phagocytosis and chemotaxis. Recent work has identified polar lipids as probable ligands for these molecules in keeping with the known evolutionary conservation of this family. CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both . in vitro and . in vivo. In addition DC are able to regulate their CD300 expression in an autocrine manner. The potential to form different CD300 heterodimers adds further complexity to their role in fine tuning DC function.Expression of CD300 molecules is altered in a number of diseases including many where DC are implicated in the pathogenesis. CD300 antibodies have been demonstrated to have significant therapeutic effect in animal models. The mechanisms underlying the immunoregulatory effects of the CD300 family are complex. Deciphering their physiology will allow effective targeting of these molecules as novel therapies in a wide variety of inflammatory diseases.
Keyword CD300
Human dendritic cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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Created: Mon, 03 Feb 2014, 01:18:05 EST by Matthew Lamb on behalf of School of Medicine