The IL-17 Differentiation Pathway and Its Role in Transplant Outcome

Serody, J.S. and Hill, G.R. (2012) The IL-17 Differentiation Pathway and Its Role in Transplant Outcome. Biology of Blood and Marrow Transplantation, 18 1 SUPPL.: S56-S61. doi:10.1016/j.bbmt.2011.10.001

Author Serody, J.S.
Hill, G.R.
Title The IL-17 Differentiation Pathway and Its Role in Transplant Outcome
Journal name Biology of Blood and Marrow Transplantation   Check publisher's open access policy
ISSN 1083-8791
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.bbmt.2011.10.001
Open Access Status DOI
Volume 18
Issue 1 SUPPL.
Start page S56
End page S61
Total pages 6
Place of publication Philadelphia, PA, U.S.A.
Publisher Elsevier Inc.
Language eng
Subject 2747 Transplantation
2720 Hematology
Abstract The limitations of allogeneic transplantation are graft-versus-host disease (both acute and chronic), infection, and relapse. Acute GVHD has traditionally been thought of as a Th1-mediated disease with inflammatory cytokines (eg, inteferon [IFN]-γ and tumor necrosis factor [TNF]) and cellular cytolysis mediating apoptotic target tissue damage in skin, gut, and liver. Chronic GVHD has not fit neatly into either Th1 or Th2 (eg, IL-4, IL-13) paradigms. Increasingly, the Th17 pathway of differentiation has been shown to play important roles in acute and chronic GVHD (aGVHD, cGVHD), particularly in relation to skin and lung disease. Here we discuss the IL-17 pathway of T cell differentiation and the accumulating evidence suggesting it represents an important new target for the control of deleterious alloimmune responses.
Keyword Bone marrow transplantation
Graft-versus-host disease
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID R01 CA166794
R01 HL115761
R56 AI084219
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 43 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 31 Jan 2014, 07:58:33 EST by Matthew Lamb on behalf of School of Medicine