Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection

Zinkernagel, M.S., Chinnery, H.R., Ong, M.L., Petitjean, C., Voigt, V., McLenachan, S., McMenamin, P.G., Hill, G.R., Forrester, J.V., Wikstrom, M.E. and Degli-Esposti, M.A. (2013) Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection. American Journal of Pathology, 182 3: 875-885. doi:10.1016/j.ajpath.2012.11.031

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Author Zinkernagel, M.S.
Chinnery, H.R.
Ong, M.L.
Petitjean, C.
Voigt, V.
McLenachan, S.
McMenamin, P.G.
Hill, G.R.
Forrester, J.V.
Wikstrom, M.E.
Degli-Esposti, M.A.
Title Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection
Journal name American Journal of Pathology   Check publisher's open access policy
ISSN 0002-9440
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ajpath.2012.11.031
Open Access Status
Volume 182
Issue 3
Start page 875
End page 885
Total pages 11
Place of publication New York, NY, U.S.A.
Publisher Elsevier Inc.
Language eng
Subject 2734 Pathology and Forensic Medicine
Abstract Microglial cells are the resident macrophages of the central nervous system and participate in both innate and adaptive immune responses but can also lead to exacerbation of neurodegenerative pathologies after viral infections. Microglia in the outer layers of the retina and the subretinal space are thought to be involved in retinal diseases where low-grade chronic inflammation and oxidative stress play a role. This study investigated the effect of systemic infection with murine cytomegalovirus on the distribution and dynamics of retinal microglia cells. Systemic infection with murine cytomegalovirus elicited a significant increase in the number of microglia in the subretinal space and an accumulation of iris macrophages, along with morphological signs of activation. Interferon γ (IFN-γ)-deficient mice failed to induce changes in microglia distribution. Bone marrow chimera experiments confirmed that microglial cells in the subretinal space were not recruited from the circulating monocyte pool, but rather represented an accumulation of resident microglial cells from within the retina. Our results demonstrate that a systemic viral infection can lead to IFN-γ-mediated accumulation of microglia into the outer retinal layers and offer proof of concept that systemic viral infections alter the ocular microenvironment and therefore, may influence the course of diseases such as macular degeneration, diabetic retinopathy, or autoimmune uveitis, where low-grade inflammation is implicated. Copyright
Keyword Pathology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 31 Jan 2014, 07:26:49 EST by Matthew Lamb on behalf of School of Medicine