Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Koyama, M., Hashimoto, D., Nagafuji, K., Eto, T., Ohno, Y., Aoyama, K., Iwasaki, H., Miyamoto, T., Hill, G.R., Akashi, K. and Teshima, T. (2014) Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning. Bone Marrow Transplantation, 49 1: 110-115. doi:10.1038/bmt.2013.134

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Author Koyama, M.
Hashimoto, D.
Nagafuji, K.
Eto, T.
Ohno, Y.
Aoyama, K.
Iwasaki, H.
Miyamoto, T.
Hill, G.R.
Akashi, K.
Teshima, T.
Title Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning
Journal name Bone Marrow Transplantation   Check publisher's open access policy
ISSN 0268-3369
1476-5365
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/bmt.2013.134
Open Access Status
Volume 49
Issue 1
Start page 110
End page 115
Total pages 6
Place of publication London, England, U.K.
Publisher Nature Publishing Group
Language eng
Subject 2720 Hematology
2747 Transplantation
Abstract Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.
Formatted abstract
Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.
Keyword Cord blood transplantation
Graft rejection
Reduced intensity conditioning
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 25293217
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Fri, 31 Jan 2014, 00:28:16 EST by Matthew Lamb on behalf of School of Medicine