CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3

Seillet, Cyril, Jackson, Jacob T., Markey, Kate A., Brady, Hugh J. M., Hill, Geoffrey R., MacDonald, Kelli P. A., Nutt, Stephen L. and Belz, Gabrielle T. (2013) CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood, 121 9: 1574-1583. doi:10.1182/blood-2012-07-445650

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Author Seillet, Cyril
Jackson, Jacob T.
Markey, Kate A.
Brady, Hugh J. M.
Hill, Geoffrey R.
MacDonald, Kelli P. A.
Nutt, Stephen L.
Belz, Gabrielle T.
Title CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
Publication date 2013-02-28
Year available 2013
Sub-type Article (original research)
DOI 10.1182/blood-2012-07-445650
Open Access Status
Volume 121
Issue 9
Start page 1574
End page 1583
Total pages 10
Place of publication Washington DC United States
Publisher American Society of Hematology
Language eng
Subject 2720 Hematology
1303 Specialist Studies in Education
1307 Cell Biology
2403 Immunology
Abstract Antiviral immunity and cross-presentation is mediated constitutively through CD8α+ and CD103+DCs. Development of these DC subsets is thought to require the transcription factors Irf8, Id2, Nfil3, and Batf3, although how this network is regulated is poorly defined. We addressed the nature of the differentiation blocks observed in the absence of these factors and found that although all 4 factors are required for CD103 +DC development, only Irf8 is essential for CD8α+ DCs. CD8α+ DCs emerged in the absence of Id2, Nfil3 and Batf3 in short-term bone marrow reconstitution. These "induced" CD8α+ DCs exhibit several hallmarks of classic CD8α+ DCs including the expression of CD24, Tlr3, Xcr1, Clec9A, and the capacity to cross-present soluble, cell-associated antigens and viral antigens even in the absence of Batf3. Collectively, these results uncover a previously undescribed pathway by which CD8α+ DCs emerge independent of Id2, Nfil3, and Batf3, but dependent on Irf8.
Keyword Hematology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Created: Fri, 31 Jan 2014, 00:03:32 EST by Matthew Lamb on behalf of School of Medicine